Department of Molecular Biosciences, University of Kansas, Lawrence, KS, 66045, USA.
Center for Reproductive Evolution, Department of Biology, Syracuse University, Syracuse, NY, 13244, USA.
BMC Res Notes. 2024 Sep 30;17(1):279. doi: 10.1186/s13104-024-06945-y.
We quantified the effect of acute exposure to a high dosage of inorganic mercury on gene expression in Drosophila melanogaster using RNA-sequencing of whole adult females.
We found 119 genes with higher gene expression following treatment (including all 5 Drosophila metallothionine genes and a number of heat shock protein genes), and 31 with lower expression (several of which are involved in egg formation). Our results highlight biological processes and genetic pathways impacted by exposure to this toxic metal, and provide motivation for future studies to understand the genetic basis of response to mercury.
我们通过对成年雌性果蝇的全基因组 RNA 测序，量化了急性暴露于高剂量无机汞对基因表达的影响。
我们发现 119 个基因在处理后表达上调（包括所有 5 个果蝇金属硫蛋白基因和一些热休克蛋白基因），31 个基因表达下调（其中一些与卵形成有关）。我们的研究结果突出了暴露于这种有毒金属所影响的生物学过程和遗传途径，并为未来研究理解汞应答的遗传基础提供了动力。
