Leiter J C, Knuth S L, Bartlett D
Am Rev Respir Dis. 1985 Dec;132(6):1242-5. doi: 10.1164/arrd.1985.132.6.1242.
Sleep deprivation appears to increase the severity of obstructive sleep apnea, and inadequate activation of the genioglossus muscle may play an important role in the pathogenesis of obstructive sleep apnea. Therefore, we investigated the effect of sleep deprivation on genioglossal electromyographic (EMG) activity. Eleven men were studied during room air breathing and CO2 rebreathing before sleep deprivation (control), after 1 night of sleep deprivation, and the day after sleep recovery. We measured inspired minute ventilation, tidal volume, respiratory frequency, and peak integrated inspiratory genioglossal EMG activity. After sleep deprivation, no significant changes in inspiratory minute ventilation or tidal volume occurred during room air breathing or CO2 rebreathing, but the breathing frequency during CO2 rebreathing increased significantly after sleep deprivation. Genioglossal EMG activity was diminished during CO2 rebreathing after sleep deprivation, but this was significant only in subjects 30 yr of age and older. The fall in EMG activity was independent of changes in tidal volume. All variables returned towards control levels after sleep recovery. We conclude that sleep deprivation selectively decreases genioglossal EMG activity during CO2 rebreathing in awake older subjects. This influence of sleep deprivation may play a role in the pathogenesis or severity of obstructive sleep apnea.
睡眠剥夺似乎会加重阻塞性睡眠呼吸暂停的严重程度，而颏舌肌激活不足可能在阻塞性睡眠呼吸暂停的发病机制中起重要作用。因此，我们研究了睡眠剥夺对颏舌肌肌电图（EMG）活动的影响。对11名男性在睡眠剥夺前（对照）、睡眠剥夺1晚后以及睡眠恢复后的第二天进行了室内空气呼吸和二氧化碳再呼吸试验。我们测量了每分钟吸气通气量、潮气量、呼吸频率以及颏舌肌吸气肌电图活动峰值。睡眠剥夺后，在室内空气呼吸或二氧化碳再呼吸期间，吸气分钟通气量或潮气量无显著变化，但睡眠剥夺后二氧化碳再呼吸期间的呼吸频率显著增加。睡眠剥夺后二氧化碳再呼吸期间颏舌肌肌电图活动减弱，但仅在30岁及以上的受试者中显著。肌电图活动的下降与潮气量的变化无关。睡眠恢复后所有变量均恢复至对照水平。我们得出结论，睡眠剥夺选择性地降低了清醒老年受试者在二氧化碳再呼吸期间的颏舌肌肌电图活动。睡眠剥夺的这种影响可能在阻塞性睡眠呼吸暂停的发病机制或严重程度中起作用。
