Leiter J C, Knuth S L, Krol R C, Bartlett D
Am Rev Respir Dis. 1985 Aug;132(2):216-9. doi: 10.1164/arrd.1985.132.2.216.
We examined the effect of diazepam on the respiratory electromyographic (EMG) activity of the genioglossal muscle using a double-blind, placebo-controlled, randomized protocol. Control measurements of minute ventilation, tidal volume, frequency, end-tidal CO2, and peak integrated inspiratory genioglossal EMG activity were made in 10 normal awake male subjects during quiet breathing and CO2 rebreathing. Subjects then received either 10 mg of diazepam orally or a placebo, and all respiratory measurements were repeated after 45 min. Each subject was studied on 2 separate days, receiving each treatment on a different day. The placebo had no effect on any of the measured variables. After diazepam, we observed an increase in end-tidal CO2 rebreathing, diazepam was associated with a reduction in minute ventilation, tidal volume, and frequency. When compared at equal end-tidal CO2 levels, genioglossal EMG activity and tidal volume were significantly reduced after diazepam. However, only older subjects demonstrated a reduction in EMG activity when compared at equal tidal volumes during CO2 rebreathing. We conclude that diazepam selectively decreases genioglossal EMG activity during CO2 rebreathing only in older subjects.
我们采用双盲、安慰剂对照、随机方案，研究了地西泮对颏舌肌呼吸肌电图（EMG）活动的影响。对10名正常清醒男性受试者在静息呼吸和重复呼吸二氧化碳期间的分钟通气量、潮气量、频率、呼气末二氧化碳分压以及吸气时颏舌肌EMG活动峰值进行了对照测量。然后，受试者口服10毫克地西泮或安慰剂，45分钟后重复所有呼吸测量。每位受试者在2个不同日期接受研究，在不同日期接受每种治疗。安慰剂对任何测量变量均无影响。服用地西泮后，我们观察到重复呼吸二氧化碳时呼气末二氧化碳分压升高，地西泮与分钟通气量、潮气量和频率降低有关。在呼气末二氧化碳水平相等时进行比较，服用地西泮后颏舌肌EMG活动和潮气量显著降低。然而，在重复呼吸二氧化碳期间，仅老年受试者在潮气量相等时EMG活动降低。我们得出结论，地西泮仅在老年受试者重复呼吸二氧化碳期间选择性降低颏舌肌EMG活动。
