Nagaoka K, Sakurami T, Nabeya N, Imura H, Kuno S
Endocrinol Jpn. 1979 Oct;26(5):599-603. doi: 10.1507/endocrj1954.26.599.
Thyroid antimicrosomal antibodies, gastric parietal cell antibodies (PCA) and antinuclear factors were studied in 208 insulin dependent diabetic (IDD) according to the duration of diabetes and patient's age at the time of testing. Antimicrosomal antibodies were found in 11 out of 47 (23.4%) IDD with the duration of less than one year, however this value declined to 13.1% at 1 to 3 years, 15.3% at 4 to 5 years, 10.8% at 6 to 10 years and 5.8% at more than 10 years. Of the 47 IDD, 7 (14.8%) were positive for gastric parietal cell antibodies. The prevalence of PCA declined with increasing duration of diabetes. However, this decrease in the prevalence of antimicrosomal antibodies and PCA was not so extreme as that of pancreatic islet cell antibodies. Antinuclear factors did not reveal a significant correlation with the duration of diabetes. In normal controls, the prevalence of antimicrosomal antibodies, PCA and the antinuclear factors increased progressively with age. In IDD, the prevalence of the antinuclear factors was also progressively greater with age. However, the prevalence of antimicrosomal antibodies in IDD decreased with age and those of PCA showed the lowest percent in the 40-69 year-age group.
根据糖尿病病程和检测时患者年龄，对208例胰岛素依赖型糖尿病（IDD）患者的甲状腺微粒体抗体、胃壁细胞抗体（PCA）和抗核因子进行了研究。在病程小于1年的47例IDD患者中，有11例（23.4%）发现有微粒体抗体，然而该数值在病程1至3年时降至13.1%，4至5年时为15.3%，6至10年时为10.8%，超过10年时为5.8%。在47例IDD患者中，7例（14.8%）胃壁细胞抗体呈阳性。PCA的患病率随糖尿病病程延长而下降。然而，微粒体抗体和PCA患病率的下降不像胰岛细胞抗体那样明显。抗核因子与糖尿病病程未显示出显著相关性。在正常对照组中，微粒体抗体、PCA和抗核因子的患病率随年龄增长而逐渐升高。在IDD患者中，抗核因子的患病率也随年龄增长而逐渐升高。然而，IDD患者中微粒体抗体的患病率随年龄下降，而PCA的患病率在40 - 69岁年龄组中最低。
