College of Life Sciences, Shandong Agricultural University, Tai'an 271018, Shandong Province, China.
World J Gastroenterol. 2024 Sep 14;30(34):3856-3861. doi: 10.3748/wjg.v30.i34.3856.
In this editorial, we comment on the article by Zhou published in a recent issue. We specifically focus on the crucial roles of ferroptosis and pyroptosis in acute liver failure (ALF), a disease with high mortality rates. Ferroptosis is the result of increased intracellular reactive oxygen species due to iron accumulation, glutathione (GSH) depletion, and decreased GSH peroxidase 4 activity, while pyroptosis is a procedural cell death mediated by gasdermin D which initiates a sustained inflammatory process. In this review, we describe the characteristics of ferroptosis and pyroptosis, and discuss the involvement of the two cell death modes in the onset and development of ALF. Furthermore, we summarize several interfering methods from the perspective of ferroptosis and pyroptosis for the alleviation of ALF. These observations might provide new targets and a theoretical basis for the treatment of ALF, which are also crucial for improving the prognosis of patients with ALF.
在这篇社论中，我们对 Zhou 近期发表的一篇文章进行评论。我们特别关注铁死亡和细胞焦亡在急性肝衰竭（ALF）中的关键作用，ALF 是一种死亡率很高的疾病。铁死亡是由于铁积累、谷胱甘肽 (GSH) 耗竭和谷胱甘肽过氧化物酶 4 活性降低导致细胞内活性氧增加引起的，而细胞焦亡是由 GSDMD 介导的程序性细胞死亡，它启动持续的炎症过程。在这篇综述中，我们描述了铁死亡和细胞焦亡的特征，并讨论了这两种细胞死亡方式在 ALF 发病和发展中的作用。此外，我们从铁死亡和细胞焦亡的角度总结了几种干预方法，以减轻 ALF。这些观察结果可能为 ALF 的治疗提供新的靶点和理论基础，这对于改善 ALF 患者的预后也至关重要。
