Samaan Sara F, Taha Sara I, Mahmoud Fatma A, Elsaadawy Yara, Khalil Salma A, Gamal Dalia M
Department of Internal Medicine and Rheumatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Clin Med Insights Arthritis Musculoskelet Disord. 2024 Sep 17;17:11795441241276880. doi: 10.1177/11795441241276880. eCollection 2024.
Although high serum levels of interleukin (IL)-17 and its producing cells have been found in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in earlier research, it is still unclear how these findings relate to disease activity.
This study examines the link between serum levels of IL-17 and the activity of both RA and SLE.
This pilot case-control study included 100 patients with RA, 100 with SLE, and 100 healthy controls.
The Disease Activity Score-28 (DAS28) scores assessed the activity of RA, whereas the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) scores assessed SLE activity. All participants' data were compared and correlated.
Serum levels of IL-17 were significantly higher in RA and SLE patients compared with the controls ( < .001) and showed significantly positive correlations ( < .001) with rheumatoid factor titer, anti-cyclic citrullinated peptide (anti-CCP) and DAS28 score among the RA patients. Although among SLE patients, they were significantly positively correlated ( < .001) with anti-double-stranded DNA (anti-ds DNA) levels and the SLEDAI-2K scores, the best cut-off value of IL-17 for predicting moderate and high disease activity was > 175 pg/mL among RA patients and > 95 pg/mL among SLE patients.
There is a significant correlation between RA and SLE activity and serum levels of IL-17. This discovery emphasizes IL-17 as a potential therapeutic target.
尽管早期研究已发现类风湿关节炎（RA）和系统性红斑狼疮（SLE）患者血清中白细胞介素（IL）-17水平较高及其产生细胞数量较多，但这些发现与疾病活动度之间的关系仍不明确。
本研究探讨IL-17血清水平与RA和SLE疾病活动度之间的联系。
本前瞻性病例对照研究纳入100例RA患者、100例SLE患者和100例健康对照。
采用疾病活动度评分28（DAS28）评估RA的疾病活动度，采用系统性红斑狼疮疾病活动指数2000（SLEDAI-2K）评估SLE的疾病活动度。比较并分析所有参与者的数据。
与健康对照相比，RA和SLE患者的血清IL-17水平显著升高（<0.001），且在RA患者中，IL-17水平与类风湿因子滴度、抗环瓜氨酸肽（抗CCP）及DAS28评分呈显著正相关（<0.001）。在SLE患者中，IL-17水平与抗双链DNA（抗dsDNA）水平及SLEDAI-2K评分也呈显著正相关（<0.001），预测RA中度及高度疾病活动度时IL-17的最佳截断值>175 pg/mL，预测SLE时为>95 pg/mL。
RA和SLE的疾病活动度与血清IL-17水平显著相关。这一发现强调IL-17是一个潜在的治疗靶点。
