Ceccarelli Fulvia, Perricone Carlo, Massaro Laura, Pacucci Viviana Antonella, Cipriano Enrica, Truglia Simona, Miranda Francesca, Spinelli Francesca Romana, Alessandri Cristiano, Valesini Guido, Conti Fabrizio
Lupus Clinic, Reumatologia, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Viale del Policlinico 155, 00161 Roma, Italy.
ScientificWorldJournal. 2014;2014:236842. doi: 10.1155/2014/236842. Epub 2014 Nov 3.
To evaluate the application of Disease Activity Score 28 (DAS28) to assess joint involvement in Systemic Lupus Erythematosus (SLE).
Sixty-nine SLE patients, complaining of joint symptoms, and 44 rheumatoid arthritis (RA) patients were enrolled. In SLE patients disease activity was assessed with SLEDAI-2K. DAS28 was calculated in all the patients.
Thirty SLE patients (43.5%) showed clinical signs of arthritis. Mean DAS28 was 4.0±1.4, 22 patients (31.9%) had low disease activity, 29 (42.0%) moderate, and 18 (26.1%) high. We dichotomized SLE patients according to the presence (Group 1) or absence (Group 2) of articular involvement according to SLEDAI-2K: 56.3% of the patients of the second group had a moderate/high activity according to DAS28. We compared SLE patients with 44 RA patients (M/F 9/35, mean age 55.6±14.5 years; mean disease duration 140.4±105.6 months). No significant differences were found regarding the values of DAS28 between SLE and RA patients. On the contrary, the values of tender and swollen joint count were significantly higher in RA compared to SLE patients (P=0.0002 and P=0.0001, resp.).
We suggest the use of the DAS28 in the assessment of joint involvement in SLE patients.
评估疾病活动评分28（DAS28）在评估系统性红斑狼疮（SLE）关节受累情况中的应用。
纳入69例有关节症状的SLE患者和44例类风湿关节炎（RA）患者。SLE患者的疾病活动度采用SLEDAI - 2K进行评估。所有患者均计算DAS28。
30例SLE患者（43.5%）出现关节炎临床体征。DAS28均值为4.0±1.4，22例患者（31.9%）疾病活动度低，29例（42.0%）中度，18例（26.1%）高度。根据SLEDAI - 2K将SLE患者分为有关节受累组（第1组）和无关节受累组（第2组）：第2组56.3%的患者根据DAS28显示为中度/高度活动。将SLE患者与44例RA患者进行比较（男/女9/35，平均年龄55.6±14.5岁；平均病程140.4±105.6个月）。SLE患者和RA患者之间DAS28值未发现显著差异。相反，RA患者的压痛关节计数和肿胀关节计数的值显著高于SLE患者（分别为P = 0.0002和P = 0.0001）。
我们建议使用DAS28评估SLE患者的关节受累情况。
