Vagopoulou Anastasia, Theofilis Panagiotis, Karasavvidou Despina, Haddad Nasra, Makridis Dimitris, Tzimikas Stergios, Kalaitzidis Rigas
Nephrology Department "C. Katsinas", General Hospital of Ptolemaida "Mpodosakeio", Ptolemaida 50200, Greece.
Center for Nephrology "G. Papadakis", General Hospital of Nikaia-Piraeus "Agios Panteleimon", Nikaia-Piraeus 18454, Greece.
World J Nephrol. 2024 Sep 25;13(3):95262. doi: 10.5527/wjn.v13.i3.95262.
Flavonoids, the main class of polyphenols, exhibit antioxidant and antihypertensive properties.
To prospectively investigate the impact of flavonoids on arterial stiffness in patients with chronic kidney disease (CKD) stages I-IV.
In this prospective, single-arm study, CKD patients with arterial hypertension and diabetes mellitus were enrolled. Baseline demographic, clinical, and laboratory variables were recorded. Patients received daily treatment with a phenol-rich dietary supplement for 3 months. Blood pressure, arterial stiffness (carotid-femoral pulse wave velocity, central pulse pressure), and oxidative stress markers (protein carbonyls, total phenolic compound, total antioxidant capacity) were measured at baseline and at study end.
Sixteen patients (mean age: 62.5 years, 87.5% male) completed the study. Following intervention, peripheral systolic blood pressure decreased significantly by 14 mmHg ( < 0.001). Carotid-femoral pulse wave velocity decreased from 8.9 m/s (baseline) to 8.2 m/s (study end) ( < 0.001), and central pulse pressure improved from 59 mmHg to 48 mmHg ( = 0.003). Flavonoids also reduced oxidative stress markers including protein carbonyls ( < 0.001), total phenolic compound ( = 0.001), and total antioxidant capacity ( = 0.013).
Flavonoid supplementation in CKD patients shows promise in improving blood pressure, arterial stiffness, and oxidative stress markers.
黄酮类化合物是多酚的主要类别，具有抗氧化和降压特性。
前瞻性研究黄酮类化合物对慢性肾脏病（CKD）I-IV期患者动脉僵硬度的影响。
在这项前瞻性单臂研究中，纳入患有动脉高血压和糖尿病的CKD患者。记录基线人口统计学、临床和实验室变量。患者接受富含酚类的膳食补充剂每日治疗3个月。在基线和研究结束时测量血压、动脉僵硬度（颈动脉-股动脉脉搏波速度、中心脉压）和氧化应激标志物（蛋白质羰基、总酚类化合物、总抗氧化能力）。
16名患者（平均年龄：62.5岁，87.5%为男性）完成了研究。干预后，外周收缩压显著降低14 mmHg（<0.001）。颈动脉-股动脉脉搏波速度从8.9 m/s（基线）降至8.2 m/s（研究结束）（<0.001），中心脉压从59 mmHg改善至48 mmHg（=0.003）。黄酮类化合物还降低了氧化应激标志物，包括蛋白质羰基（<0.001）、总酚类化合物（=0.001）和总抗氧化能力（=0.013）。
对CKD患者补充黄酮类化合物在改善血压、动脉僵硬度和氧化应激标志物方面显示出前景。
