Ladak Nurfiza, Liu Ying, Burke Amanda, Lin Oscar, Chan Alexander
Department of Pathology, Hematopathology Service, Memorial Sloan Kettering Cancer Center, United States.
Hum Pathol Rep. 2024 Sep;37. doi: 10.1016/j.hpr.2024.300753. Epub 2024 Jul 22.
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia characterized by an abnormal proliferation of promyelocytes. It is often associated with an aggressive clinical presentation involving complex coagulopathies including disseminated intravascular coagulation, with a significant risk of bleeding and/or thrombosis if treatment with all--retinoic acid (ATRA) is not rapidly initiated. Here we present a unique case of APL which was isolated to femoral bone lesions, without definitive evidence of peripheral blood or bone marrow involvement, and without systemic sequelae.
急性早幼粒细胞白血病（APL）是急性髓系白血病的一种亚型，其特征为早幼粒细胞异常增殖。它常伴有侵袭性临床表现，包括复杂的凝血功能障碍，如弥散性血管内凝血，如果不迅速开始使用全反式维甲酸（ATRA）治疗，有显著的出血和/或血栓形成风险。在此，我们报告一例独特的APL病例，该病例仅局限于股骨骨病变，无外周血或骨髓受累的确切证据，也无全身后遗症。
