色甘酸钠预防运动诱发性哮喘的效果。

The effect of sodium crompromate in the prevention of exercise-induced asthma.

作者信息

Fu Y X, Ye S T, Xia L Y

出版信息

Asian Pac J Allergy Immunol. 1985 Dec;3(2):147-50.

Abstract

Sodium crompromate (SCP) is an isomer of disodium cromoglycate (DSCG). The two chemicals are pharmacologically similar but with different chemical synthesis. A comparative double-blind latin square study of the preventive effect of SCP and DSCG versus a placebo aerosol was carried out on a group of nine cases of exercise-induced asthma (EIA). Compared with the placebo, both SCP and DSCG were able to prevent asthma under exercise provocation, as monitored by chest auscultation and FEV1. There was no significant difference in the percentage fall of FEV1 on challenge. This suggests that SCP has a similar prophylactic effect as that of DSCG on EIA.

摘要

色甘酸钠（SCP）是色甘酸二钠（DSCG）的异构体。这两种化学物质在药理上相似，但化学合成方法不同。对一组9例运动诱发性哮喘（EIA）患者进行了一项比较双盲拉丁方研究，比较SCP和DSCG与安慰剂气雾剂的预防效果。通过胸部听诊和第一秒用力呼气量（FEV1）监测发现，与安慰剂相比，SCP和DSCG在运动激发试验下均能预防哮喘发作。激发试验时FEV1下降的百分比没有显著差异。这表明SCP对EIA的预防作用与DSCG相似。