Sulkowska Joanna, Melles Aikilu Woldegabriel, Skranes Julia Brox, Berge Trygve, Tveit Arnljot, Røsjø Helge, Lyngbakken Magnus Nakrem, Omland Torbjørn, Heck Siri Lagethon
K.G. Jebsen Center for Cardiac Biomarkers, Institute of Clinical Medicine, University of Oslo, Campus Akershus University Hospital, P.b. 1000 NO-1478 Lørenskog, Norway.
Department of Diagnostic Imaging, Akershus University Hospital, Sykehusveien 25, Nordbyhagen, 1478 Lørenskog, Norway.
Eur Heart J Imaging Methods Pract. 2024 Jul 30;2(3):qyae078. doi: 10.1093/ehjimp/qyae078. eCollection 2024 Jul.
Cardiac troponin T (cTnT) is a blood biomarker of myocardial injury that is associated with future adverse cardiovascular events in the general population. Left ventricular (LV) global longitudinal strain (GLS) and mechanical dispersion (MD) are metrics of systolic function and synchrony that can be obtained from cardiac imaging. Studies suggest an association between cTnT and echocardiographically assessed GLS and MD, but it is unknown whether cTnT relates to these metrics when assessed by cardiac magnetic resonance (CMR). We hypothesized that cTnT associates with GLS and with MD assessed by CMR feature tracking (CMR-FT) in the general population.
cTnT and CMR-FT measurements were performed in 186 community dwellers from the Akershus Cardiac Examination 1950 Study. The participants' age ranged from 68 to 70 years. Median cTnT concentration was 7.0 ng/L (interquartile interval 5.0-12.6 ng/L), median absolute value of GLS was 17.3% (interquartile interval 15.7-18.8%), and median MD was 80.7 milliseconds (interquartile interval 61.8-105.0 milliseconds). In multivariable linear regression models adjusted for common clinical risk factors of cardiovascular disease, with GLS and MD as outcome and cTnT as the predictor variable of interest, log transformed cTnT was significantly associated with both absolute GLS [β-coefficient -1.65, confidence interval (-2.84, -0.46)] and MD [β-coefficient 28.56, confidence interval (12.14, 44.92)].
In older adults from the general population, higher cTnT concentrations are associated with worse systolic function and synchrony assessed by CMR-FT LV GLS and MD, adding information about myocardial function to traditional risk factors.
心肌肌钙蛋白T（cTnT）是心肌损伤的一种血液生物标志物，与普通人群未来发生的不良心血管事件相关。左心室（LV）整体纵向应变（GLS）和机械离散度（MD）是可通过心脏成像获得的收缩功能和同步性指标。研究表明cTnT与超声心动图评估的GLS和MD之间存在关联，但尚不清楚通过心脏磁共振（CMR）评估时cTnT是否与这些指标相关。我们假设在普通人群中，cTnT与通过CMR特征追踪（CMR-FT）评估的GLS和MD相关。
对来自1950年阿克什胡斯心脏检查研究的186名社区居民进行了cTnT和CMR-FT测量。参与者年龄在68至70岁之间。cTnT浓度中位数为7.0 ng/L（四分位间距5.0 - 12.6 ng/L），GLS绝对值中位数为17.3%（四分位间距15.7 - 18.8%），MD中位数为80.7毫秒（四分位间距61.8 - 105.0毫秒）。在针对心血管疾病常见临床危险因素进行调整的多变量线性回归模型中，以GLS和MD为结果变量，cTnT为感兴趣的预测变量，对数转换后的cTnT与绝对GLS [β系数 -1.65，置信区间（-2.84，-0.46）]和MD [β系数28.56，置信区间（12.14，44.92）]均显著相关。
在普通人群的老年人中，较高的cTnT浓度与通过CMR-FT评估的LV GLS和MD所反映的更差收缩功能和同步性相关，为传统危险因素增添了有关心肌功能的信息。
