Zhang Yong, Li Jing
Department of Clinical Laboratory, The Affiliated Lianyungang Oriental Hospital of Kangda College of Nanjing Medical University, Lianyungang 222042, Jiangsu Province, China.
Department of Respiratory and Critical Care Medicine, The Affiliated Lianyungang Oriental Hospital of Kangda College of Nanjing Medical University, Lianyungang 222042, Jiangsu Province, China.
World J Clin Oncol. 2024 Sep 24;15(9):1168-1176. doi: 10.5306/wjco.v15.i9.1168.
Homeobox (HOX) C9, a member of the HOX family, is an important transcription factor, and it plays a significant role in various biological processes. This family of genes is highly valued for their essential roles in establishing and maintaining the body axis during embryonic development and adult tissues. Further, HOXC9 plays a central role in neuronal differentiation, angiogenesis, and adipose distribution, which are essential for the development of the nervous system, maturation of tissues and organs, and maintenance of energy balance and metabolic health. Recent research has found that abnormal HOXC9 expression is closely associated with the development and progression of various tumor types. The HOXC9 expression level can be an indicator of tumor prognosis. Therefore, elucidating the association between HOXC9 expression and its regulatory mechanisms and tumorigenesis can provide novel insights on the diagnosis and treatment of patients with cancer.
同源框（HOX）C9是HOX家族的一员，是一种重要的转录因子，在各种生物学过程中发挥着重要作用。该基因家族因其在胚胎发育和成年组织中建立和维持身体轴的关键作用而受到高度重视。此外，HOXC9在神经元分化、血管生成和脂肪分布中起核心作用，这些对于神经系统的发育、组织和器官的成熟以及能量平衡和代谢健康的维持至关重要。最近的研究发现，HOXC9表达异常与多种肿瘤类型的发生和发展密切相关。HOXC9表达水平可作为肿瘤预后的一个指标。因此，阐明HOXC9表达与其调控机制以及肿瘤发生之间的关联可为癌症患者的诊断和治疗提供新的见解。
