Ono Takashi, Kaida Tomoko, Higashi Shizuka, Mori Yosai, Nejima Ryohei, Iwasaki Takuya, Kagaya Fumie, Miyai Takashi, Miyata Kazunori
Department of Ophthalmology, Miyata Eye Hospital, Miyazaki, Japan.
Department of Ophthalmology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Cutan Ocul Toxicol. 2024 Dec;43(4):335-340. doi: 10.1080/15569527.2024.2408685. Epub 2024 Oct 1.
There is a lack of long-term and large-scale studies on the adverse effects of soft contact lenses (SCLs) on the corneal endothelia of Asian populations. Here, we aimed to examine the effects of long-term SCL use on corneal endothelial density and morphology.
This retrospective study involved consecutive patients at the Miyata Eye Hospital (Miyazaki, Japan), who had used SCLs for more than 1 year. Patients with ophthalmological disorders without refractive errors were excluded. The period of SCL use, SCL type, corneal endothelial cell density (ECD), appearance rate of hexagonal cells (HEX), and coefficient of variation of cells (CV) were analyzed.
In total, 17,732 eyes of 8866 patients were included in the analysis (age, 26.0 ± 8.8 years). The mean period of SCL use was 6.3 ± 5.4 years. Multivariate regression analysis revealed that ECD and HEX were significantly negatively correlated with the period of SCL use, age, and sex ( < 0.001 for all). The CV was significantly positively correlated with the period of use ( < 0.001), sex ( = 0.002), and age ( < 0.001).
Corneal ECD, HEX, and CV were significantly associated with the period of SCL use in long-term users. It is essential to regularly check the corneal endothelium in patients with a history of long-term SCL use.
缺乏关于软性隐形眼镜（SCL）对亚洲人群角膜内皮细胞不良反应的长期大规模研究。在此，我们旨在研究长期使用SCL对角膜内皮细胞密度和形态的影响。
这项回顾性研究纳入了日本宫崎县宫田眼科医院连续使用SCL超过1年的患者。排除无屈光不正的眼科疾病患者。分析了SCL使用时间、SCL类型、角膜内皮细胞密度（ECD）、六角形细胞出现率（HEX）和细胞变异系数（CV）。
总共8866例患者的17732只眼纳入分析（年龄26.0±8.8岁）。SCL的平均使用时间为6.3±5.4年。多因素回归分析显示，ECD和HEX与SCL使用时间、年龄和性别均呈显著负相关（均P<0.001）。CV与使用时间（P<0.001）、性别（P=0.002）和年龄（P<0.001）呈显著正相关。
长期使用SCL者的角膜ECD、HEX和CV与SCL使用时间显著相关。对于有长期使用SCL病史的患者，定期检查角膜内皮至关重要。
