Federal Research Center Institute of Cytology and Genetics, Research Institute of Clinical and Experimental Lymphology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Novosibirsk Regional Clinical Oncology Dispensary, Novosibirsk, Russia.
Bull Exp Biol Med. 2024 Sep;177(5):662-667. doi: 10.1007/s10517-024-06245-2. Epub 2024 Oct 1.
The structural organization of the extracellular matrix of rectal adenocarcinoma of different differentiation degrees without and after neoadjuvant radiation therapy was studied on postoperative material using immunohistochemistry and electron microscopy. The differences in the expression of types I and III collagens, as well as in the ultrastructural organization of the extracellular matrix of rectal adenocarcinoma of different differentiation degrees without and after neoadjuvant radiation therapy were revealed. We observed high expression of collagen I and wide channels in the collagen matrix in the central areas of the well differentiated adenocarcinomas without neoadjuvant radiation therapy and in poorly differentiated adenocarcinomas after neoadjuvant radiation therapy, which can be associated with metastasis and poor prognosis for the patients.
采用免疫组织化学和电子显微镜技术，研究了不同分化程度的直肠腺癌在新辅助放疗前后的细胞外基质的结构组织。结果揭示了不同分化程度的直肠腺癌在新辅助放疗前后细胞外基质中 I 型和 III 型胶原的表达以及超微结构组织的差异。我们观察到，在未接受新辅助放疗的高分化腺癌和接受新辅助放疗后的低分化腺癌的中心区域，I 型胶原表达较高，胶原基质中存在宽阔的通道，这可能与转移和患者预后不良有关。
