Department of Orthopaedics, Honghui Hospital, Xi'an Jiao Tong University, Xi'an, 710000, China.
Department of Medical Services Section, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shen'zhen, 518107, China.
Sci Rep. 2024 Jul 9;14(1):15849. doi: 10.1038/s41598-024-66859-4.
Dietary antioxidants may have beneficial effects on bone health, but it remains uncertain in children and adolescents. This study investigates the association of composite dietary antioxidant index (CDAI) with bone mineral density (BMD) in children and adolescents aged 8-19 years from the National Health and Nutrition Examination Survey (NHANES) 2007-2010. The study assessed the relationship between CDAI and BMD in 2994 individuals aged 8-19 years (average age 13.48 ± 3.32 years) from the NHANES 2007-2010. Multivariate linear regression analyses were utilized to detect the association between CDAI and total spine, femur neck, and total femur BMD, adjusting for confounders including age, race/ethnicity, sex, poverty income ratio (PIR), body mass index (BMI), serum phosphorus and calcium. Stratified analyses and interaction tests were performed to examine the stability of the results. The weighted characteristics showed that subjects in the fourth CDAI quartile were more likely to be older, men, and Non-Hispanic White. They have higher values of serum total calcium and phosphorus. After adjusting all confounders, CDAI was positively associated with the total spine (β = 0.0031 95% CI 0.0021-0.0040), total femur (β = 0.0039 95% CI 0.0028-0.0049), and femur neck BMD (β = 0.0031 95% CI 0.0021-0.0040) in children and adolescents. Furthermore, we found no interaction effects between different race/ethnicity, age, and sex groups. Our findings suggest that dietary intake of multiple antioxidants was positively associated with BMD in children and adolescents. These findings provide valuable evidence for improving bone health in the early stages of life. However, more prospective studies are required to validate our findings and their causal relationship.
膳食抗氧化剂可能对骨骼健康有益，但在儿童和青少年中尚不确定。本研究调查了复合膳食抗氧化指数（CDAI）与 2007-2010 年国家健康和营养检查调查（NHANES）中 8-19 岁儿童和青少年骨矿物质密度（BMD）之间的关系。该研究评估了 CDAI 与 2007-2010 年 NHANES 中 2994 名 8-19 岁个体（平均年龄 13.48±3.32 岁）BMD 之间的关系。利用多元线性回归分析来检测 CDAI 与总脊柱、股骨颈和总股骨 BMD 之间的关联，同时调整了包括年龄、种族/民族、性别、贫困收入比（PIR）、体重指数（BMI）、血清磷和钙在内的混杂因素。进行了分层分析和交互测试以检验结果的稳定性。加权特征表明，第四 CDAI 四分位数的受试者年龄更大、为男性且为非西班牙裔白人。他们的血清总钙和磷值更高。在调整所有混杂因素后，CDAI 与总脊柱（β=0.0031 95%CI 0.0021-0.0040）、总股骨（β=0.0039 95%CI 0.0028-0.0049）和股骨颈 BMD（β=0.0031 95%CI 0.0021-0.0040）呈正相关。此外，我们没有发现不同种族/民族、年龄和性别组之间存在交互作用。我们的研究结果表明，多种抗氧化剂的膳食摄入与儿童和青少年的 BMD 呈正相关。这些发现为改善生命早期的骨骼健康提供了有价值的证据。然而，需要更多的前瞻性研究来验证我们的发现及其因果关系。
