Patrick Sarah L, Bull James A, Miller Philip W, Crimmin Mark R
Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, Shepherds Bush, London, W12 0BZ, U.K.
Org Lett. 2024 Oct 11;26(40):8605-8609. doi: 10.1021/acs.orglett.4c03274. Epub 2024 Oct 1.
A continuous flow process has been developed for the defluorosilylation of trifluoromethane (HFC-23) and 2,3,3,3-tetrafluoropropene (HFO-1234yf) through reaction with lithium silanide reagents under inert conditions. Design of experiment optimization improved process conditions, including productivity, yields, reduction of solvent use, and gas destruction. The small chain fluorinated organosilane products RSiCFH and RSiCHC(F)═CF were competent nucleophiles in the fluoride-catalyzed difluoromethylation of aldehydes, and trifluoroallylation of aldehydes, ketones, and imines.
已经开发出一种连续流动工艺，用于在惰性条件下通过与硅化锂试剂反应，对三氟甲烷（HFC - 23）和2,3,3,3 - 四氟丙烯（HFO - 1234yf）进行脱氟硅烷化反应。实验设计优化改进了工艺条件，包括提高生产率、产率、减少溶剂使用以及气体销毁。小链氟化有机硅烷产物RSiCFH和RSiCHC(F)═CF在氟化物催化的醛的二氟甲基化反应以及醛、酮和亚胺的三氟烯丙基化反应中是有效的亲核试剂。
