Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA.
Gut Microbes. 2024 Jan-Dec;16(1):2409209. doi: 10.1080/19490976.2024.2409209. Epub 2024 Oct 1.
The gut microbiota can produce a variety of microbial-derived metabolites to influence tumor development. Tryptophan, an essential amino acid in the human body, can be converted by microorganisms via the indole pathway to indole metabolites such as Indole-3-Lactic Acid (ILA), Indole-3-Propionic Acid (IPA), Indole Acetic Acid (IAA) and Indole-3-Aldehyde (IAld). Recent studies have shown that indole metabolites play key roles in tumor progression, and they can be used as adjuvant regimens for tumor immunotherapy or chemotherapy. Here, we summarize recent findings on the common microbial indole metabolites and provide a review of the mechanisms of different indole metabolites in the tumor microenvironment. We further discuss the limitations of current indole metabolite research and future possibilities. It is expected that microbial indole metabolites will provide new strategies for clinical therapy.
肠道微生物群可以产生多种微生物衍生代谢物来影响肿瘤的发展。色氨酸是人体必需的氨基酸，可通过微生物吲哚途径转化为吲哚代谢物，如吲哚-3-乳酸（ILA）、吲哚-3-丙酸（IPA）、吲哚乙酸（IAA）和吲哚-3-乙醛（IAld）。最近的研究表明，吲哚代谢物在肿瘤进展中起着关键作用，它们可以作为肿瘤免疫治疗或化疗的辅助方案。在这里，我们总结了常见微生物吲哚代谢物的最新发现，并综述了不同吲哚代谢物在肿瘤微环境中的作用机制。我们进一步讨论了当前吲哚代谢物研究的局限性和未来的可能性。预计微生物吲哚代谢物将为临床治疗提供新的策略。
