Photoceutics and Regeneration Laboratory, Centre for Microfluidics, Biomarkers, Photoceutics and Sensors (μBioPS), Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, India.
Int Wound J. 2024 Oct;21(10):e70070. doi: 10.1111/iwj.70070.
With advancements in naval warfare, the number and severity of seawater injuries have skyrocketed, necessitating effective seawater immersion (SWI) wound management. The unique marine pathogens, salinity, low temperature and alkalinity of seawater are the main environmental factors that can influence SWI wound healing. The current treatment strategy for SWI wounds follows a standard protocol based on terrestrial wound conditions, neglecting seawater conditions. The key requirements for ideal SWI treatment include good adhesion to the wound surface to minimize further exposure to seawater, enhanced wound healing properties to minimize wound healing time and antibacterial properties to prevent infections from marine pathogens. Current SWI wound-specific treatments range from elaborate techniques like vacuum-sealed drainage and vacuum-assisted closure for severe blast injuries to simple application of hydrogels or collagen dressings for minor injuries. This review discusses the current status and development of various treatment modalities for SWI wounds. The development of these treatment strategies and an understanding of their mechanisms of action make us better prepared to manage and treat SWI injuries.
随着海战的发展,海水伤的数量和严重程度急剧上升,这就需要对海水浸渍伤(SWI)进行有效的伤口管理。海水独特的海洋病原体、盐度、低温和碱性是影响 SWI 伤口愈合的主要环境因素。目前 SWI 伤口的治疗策略是基于陆地伤口条件的标准方案,忽略了海水条件。理想的 SWI 治疗的关键要求包括:与伤口表面良好的粘附性,以最大程度地减少进一步暴露于海水中;增强伤口愈合特性,以最大程度地减少伤口愈合时间;以及抗菌特性,以防止海洋病原体感染。目前针对 SWI 伤口的特定治疗方法包括从真空密封引流和真空辅助闭合等复杂技术,适用于严重爆炸伤,到简单应用水凝胶或胶原蛋白敷料等适用于轻度损伤。本文讨论了各种 SWI 伤口治疗方法的现状和进展。这些治疗策略的发展以及对其作用机制的理解,使我们能够更好地准备管理和治疗 SWI 损伤。