Department of Burn and Plastic Surgery, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Int Wound J. 2021 Oct;18(5):639-646. doi: 10.1111/iwj.13565. Epub 2021 Mar 30.
The aim of this study was to investigate the therapeutic effects of vacuum sealing drainage (VSD) on wound repair time and inflammation-related indicators in patients with soft-tissue wounds in comparison with traditional treatment. From January 2018 to January 2020, 130 enrolled patients with soft-tissue wounds were randomly divided into two groups: VSD group (65 cases) and routine dressing change (RDC) group (65 cases). The inflammation-related indicators including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), white blood cell (WBC), and procalcitonin (PCT) of preoperative stage and postoperative day 3 (POD 3) and POD 7 were recorded. Wound healing was observed 3 and 7 days after treatment, and the clinical efficacy, changes in the wound (coverage rate and thickness of granulation tissue and bacterial clearance rate), wound-cleaning time, wound-healing time, and hospital stay time were recorded after treatment as well. No significant difference was observed in terms of the baseline between the two groups. On POD 3 and POD 7, CRP, WBC, and PCT levels in the VSD group were lower than those in the RDC group, while ESR levels were higher, with significant differences (P < .05). After treatment, the wound-cleaning time, wound-healing time, and hospital length of stay of the VSD group were all lower than those of the RDC group, with significant differences (P < .05). VSD has a significant effect on the treatment of patients with soft-tissue wounds, which can effectively shorten the time of wound healing and reduce inflammation-related indicators. Compared with traditional RDC, VSD is more worthy of clinical application.
本研究旨在探讨真空密封引流（VSD）在软组织伤口患者的伤口修复时间和炎症相关指标方面的治疗效果，并与传统治疗进行比较。2018 年 1 月至 2020 年 1 月，纳入的 130 例软组织伤口患者被随机分为两组：VSD 组（65 例）和常规换药（RDC）组（65 例）。记录术前阶段和术后第 3 天（POD3）和第 7 天（POD7）的炎症相关指标，包括红细胞沉降率（ESR）、C 反应蛋白（CRP）、白细胞（WBC）和降钙素原（PCT）。治疗后 3 天和 7 天观察伤口愈合情况，并记录临床疗效、伤口变化（覆盖率和肉芽组织厚度以及细菌清除率）、伤口清洁时间、伤口愈合时间和住院时间。两组患者的基线资料差异无统计学意义。在 POD3 和 POD7，VSD 组的 CRP、WBC 和 PCT 水平低于 RDC 组，而 ESR 水平较高，差异有统计学意义（P<0.05）。治疗后，VSD 组的伤口清洁时间、伤口愈合时间和住院时间均低于 RDC 组，差异有统计学意义（P<0.05）。VSD 对软组织伤口患者的治疗效果显著，能有效缩短伤口愈合时间，降低炎症相关指标。与传统的 RDC 相比，VSD 更值得临床应用。
