Yin Hong, Blomberg Vilma, Sun Liwei, Yin ChunXia, Sütterlin Susanne
Department of Clinical Microbiology, Linköping University Hospital, Linköping, Sweden.
Department of Clinical Microbiology, Falu Hospital, Falun, Sweden.
Am J Perinatol. 2025 Apr;42(6):822-826. doi: 10.1055/a-2427-9065. Epub 2024 Oct 1.
The aim of the study was to investigate the virulence factors in producing extended-spectrum β-lactamase (ESBL) derived from the perinatal fecal colonization flora of mothers and their newborns in a Chinese obstetric ward.Rectal swabs were obtained from mothers prenatally and from their newborns postnatally, and analyzed for ESBL-producing . The isolates were then whole-genome sequenced.Maternal and neonatal colonization by ESBL-producing in a Chinese obstetric ward was 18% (31/177) and 5% (9/170), respectively. Fecal ESBL-producing isolates exhibited a significantly lower frequency of virulence factors compared with invasive .Providing balanced information on screening results is essential, along with conducting a risk assessment for antibiotic treatment strategies. · High ESBL E. coli colonization rates in mothers and neonates perinatally. · Fecal ESBL-producing E. coli showed fewer virulence traits.. · ESBL-producing E. coli knowledge may prompt antibiotic overuse..
本研究的目的是调查中国一家产科病房中母亲及其新生儿围产期粪便定植菌群产生超广谱β-内酰胺酶（ESBL）的毒力因子。产前从母亲以及产后从其新生儿采集直肠拭子，并分析产ESBL情况。然后对分离株进行全基因组测序。在中国一家产科病房中，母亲和新生儿产ESBL的定植率分别为18%（31/177）和5%（9/170）。与侵袭性分离株相比，粪便中产ESBL的分离株毒力因子频率显著更低。提供关于筛查结果的平衡信息至关重要，同时对抗生素治疗策略进行风险评估。· 母亲和新生儿围产期产ESBL大肠杆菌定植率高。· 粪便中产ESBL大肠杆菌的毒力特征较少。· 产ESBL大肠杆菌的相关知识可能会促使抗生素过度使用。
