Biotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Thoracic Surgery Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Sci Data. 2024 Oct 1;11(1):1064. doi: 10.1038/s41597-024-03885-x.
Examining tumor-associated macrophages in the immune microenvironment of non-small cell lung cancer (NSCLC) is essential for gaining an understanding of the genesis and development of NSCLC as well as for identifying key clinical therapeutic targets. Although previous studies have reported the diverse phenotypes and functions of macrophages in tumor tissues, thereby highlighting their significant role in the tumor microenvironment, the characteristic differences and correlations between tumor and peritumor tissue-derived macrophages that are necessary for an understanding of NSCLC progression remain unclear. Based on single-cell RNA sequencing, we generated a comprehensive dataset of transcriptomes from NSCLC tumor and peritumor tissues, thereby facilitating comprehensive analysis and providing significant insights. In summary, our dataset will serve as a valuable transcriptomic resource for further studies investigating NSCLC development.
研究非小细胞肺癌（NSCLC）免疫微环境中的肿瘤相关巨噬细胞，对于了解 NSCLC 的发生发展以及确定关键的临床治疗靶点至关重要。虽然之前的研究已经报道了巨噬细胞在肿瘤组织中的多种表型和功能，从而突出了它们在肿瘤微环境中的重要作用，但对于理解 NSCLC 进展所需的肿瘤和肿瘤周围组织来源的巨噬细胞之间的特征差异和相关性仍不清楚。基于单细胞 RNA 测序，我们生成了 NSCLC 肿瘤和肿瘤周围组织转录组的全面数据集，从而促进了全面分析并提供了重要的见解。总之，我们的数据集将作为一个有价值的转录组资源，用于进一步研究 NSCLC 的发展。
