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工作记忆期间小鼠前额叶皮层的区域性信息处理差异。

Divergent subregional information processing in mouse prefrontal cortex during working memory.

机构信息

Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA.

Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA.

出版信息

Commun Biol. 2024 Oct 1;7(1):1235. doi: 10.1038/s42003-024-06926-8.

DOI:10.1038/s42003-024-06926-8
PMID:39354065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11445572/
Abstract

Working memory (WM) is a critical cognitive function allowing recent information to be temporarily held in mind to inform future action. This process depends on coordination between prefrontal cortex (PFC) subregions and other connected brain areas. However, few studies have examined the degree of functional specialization between these subregions throughout WM using electrophysiological recordings in freely-moving mice. Here we record single-units in three neighboring mouse medial PFC (mPFC) subregions-supplementary motor area (MOs), dorsomedial PFC (dmPFC), and ventromedial (vmPFC)-during a freely-behaving non-match-to-position WM task. The MOs is most active around task phase transitions, when it transiently represents the starting sample location. Dorsomedial PFC contains a stable population code, including persistent sample-location-specific firing during the delay period. Ventromedial PFC responds most strongly to reward-related information during choices. Our results reveal subregionally segregated WM computation in mPFC and motivate more precise consideration of the dynamic neural activity required for WM.

摘要

工作记忆（WM）是一种关键的认知功能，允许暂时将最近的信息保留在脑海中，以告知未来的行动。这个过程依赖于前额叶皮层（PFC）的各个子区域和其他连接的大脑区域之间的协调。然而，很少有研究使用自由活动的小鼠中的电生理记录来检查 WM 过程中这些子区域之间的功能专业化程度。在这里，我们在三个相邻的小鼠内侧前额叶皮层（mPFC）子区域-辅助运动区（MOs）、背内侧前额叶皮层（dmPFC）和腹内侧（vmPFC）-中记录了单个单元，在自由行为的非匹配位置 WM 任务中。MOs 在任务阶段转换时最为活跃，此时它会短暂地表示起始样本位置。背内侧前额叶皮层包含稳定的群体编码，包括在延迟期间持续的样本位置特异性放电。腹内侧前额叶皮层在选择时对与奖励相关的信息反应最为强烈。我们的结果揭示了 mPFC 中区域分离的 WM 计算，并促使更精确地考虑 WM 所需的动态神经活动。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9045/11445572/cd8ba59365b7/42003_2024_6926_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9045/11445572/31f947c054fd/42003_2024_6926_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9045/11445572/7d4f1601bda5/42003_2024_6926_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9045/11445572/edb4f56ec407/42003_2024_6926_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9045/11445572/e6f9cb63db63/42003_2024_6926_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9045/11445572/02399aecf60e/42003_2024_6926_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9045/11445572/0417ec28c1a4/42003_2024_6926_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9045/11445572/498669a02ac6/42003_2024_6926_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9045/11445572/cd8ba59365b7/42003_2024_6926_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9045/11445572/31f947c054fd/42003_2024_6926_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9045/11445572/7d4f1601bda5/42003_2024_6926_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9045/11445572/edb4f56ec407/42003_2024_6926_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9045/11445572/e6f9cb63db63/42003_2024_6926_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9045/11445572/02399aecf60e/42003_2024_6926_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9045/11445572/0417ec28c1a4/42003_2024_6926_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9045/11445572/498669a02ac6/42003_2024_6926_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9045/11445572/cd8ba59365b7/42003_2024_6926_Fig8_HTML.jpg

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3
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4
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5
Theory of the Multiregional Neocortex: Large-Scale Neural Dynamics and Distributed Cognition.理论的多区域新皮质:大规模的神经动力学和分布式认知。
Annu Rev Neurosci. 2022 Jul 8;45:533-560. doi: 10.1146/annurev-neuro-110920-035434.
6
Cortical-subcortical interactions in goal-directed behavior.皮层-皮层下相互作用在目标导向行为中的作用。
Physiol Rev. 2023 Jan 1;103(1):347-389. doi: 10.1152/physrev.00048.2021. Epub 2022 Jun 30.
7
Multiple timescales of sensory-evidence accumulation across the dorsal cortex.背侧皮层中跨多个时间尺度的感觉证据积累。
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8
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9
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