Fu Lili, Huang Yan, Shan Xin, Sun Xiao, Wang Xinlei, Wang Xiaoyan, Chen Lingxin, Yu Shui
School of Pharmacy, Binzhou Medical University, Yantai, 264003, China.
College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan, Shandong, 250014, China.
J Nanobiotechnology. 2024 Oct 1;22(1):595. doi: 10.1186/s12951-024-02878-7.
Therapeutic approaches that combine conventional photodynamic therapy (PDT) with gas therapy (GT) to sensitize PDT are an attractive strategy, but the molecular structure design of the complex lacks effective guiding strategies.
Herein, we have developed a nanoplatforms Cy-NMNO@SiO based on mesoporous silica materials loaded NIR-activatable small-molecule fluorescent probe Cy-NMNO for the synergistic treatment of photodynamic therapy/gas therapy (PDT/GT) in antibacterial and skin cancer. The theoretical calculation results showed that the low dissociation of N-NO in Cy-NMNO enabled it to dissociate effectively under NIR light irradiation, which is conducive to produce Cy and NO. Cy showed better O generation performance than Cy-NMNO. The cytotoxicity of Cy-NMNO obtained via the synergistic effect of GT and PDT synergistically enhances the effect of photodynamic therapy, thus achieving more effective tumor treatment and sterilization than conventional PDT. Moreover, the nanoplatforms Cy-NMNO@SiO realized efficient drug loading and drug delivery.
This work not only offers a promising approach for PDT-GT synergistic drug delivery system, but also provides a valuable reference for the design of its drug molecules.
将传统光动力疗法（PDT）与气体疗法（GT）相结合以提高PDT敏感性的治疗方法是一种有吸引力的策略，但复合物的分子结构设计缺乏有效的指导策略。
在此，我们基于负载近红外可激活小分子荧光探针Cy-NMNO的介孔二氧化硅材料开发了一种纳米平台Cy-NMNO@SiO，用于在抗菌和皮肤癌中协同治疗光动力疗法/气体疗法（PDT/GT）。理论计算结果表明，Cy-NMNO中N-NO的低解离使其能够在近红外光照射下有效解离，有利于产生Cy和NO。Cy显示出比Cy-NMNO更好的O生成性能。通过GT和PDT的协同作用获得的Cy-NMNO的细胞毒性协同增强了光动力疗法的效果，从而比传统PDT实现了更有效的肿瘤治疗和杀菌。此外，纳米平台Cy-NMNO@SiO实现了高效的药物负载和药物递送。
这项工作不仅为PDT-GT协同药物递送系统提供了一种有前景的方法，也为其药物分子的设计提供了有价值的参考。
