Peng Boyuan, Wang Lianhao, Han Guangli, Cheng Yong
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, No.237, Luo Yu Road, Hongshan District, Wuhan City, 430079, China.
Department of Orthodontics Division II, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.
Stem Cell Res Ther. 2024 Oct 1;15(1):342. doi: 10.1186/s13287-024-03962-3.
Orthodontic relapse (OR) occurs at a rate of over 70%. Retention is the current attempt at prevention, but it requires a considerable amount of time and cannot fully block OR. It's imperative to find a safe and effective method for managing post-orthodontic tooth stability. Periodontal bone remodeling is one crucial biological foundation of OR. Mesenchymal stem cell-derived exosomes (MSC-Exo) show promise in relapse management by regulating periodontal bone remodeling. MSC-Exo can prevent relapse by regulating periodontal ligament function, osteoclast activity, osteoblast differentiation, macrophage polarization, and periodontal microcirculation. In recent years, exosome-loaded hydrogels, which achieve controlled exosome release, have demonstrated efficacy in promoting bone regeneration and remodeling, offering promising prospects for OR management. This review aims to highlight the use of MSC-Exo-based therapy for preventing OR, offering new insights for future research focused on improving tooth stability and enhancing orthodontic anchorage.
正畸复发（OR）的发生率超过70%。保持是目前预防复发的手段，但这需要相当长的时间，且无法完全阻止正畸复发。因此，必须找到一种安全有效的方法来维持正畸后牙齿的稳定性。牙周骨重塑是正畸复发的一个关键生物学基础。间充质干细胞衍生外泌体（MSC-Exo）在通过调节牙周骨重塑来控制复发方面显示出前景。MSC-Exo可通过调节牙周韧带功能、破骨细胞活性、成骨细胞分化、巨噬细胞极化和牙周微循环来预防复发。近年来，能够实现外泌体可控释放的载外泌体水凝胶已在促进骨再生和重塑方面显示出效果，为正畸复发的控制提供了广阔前景。本文综述旨在强调基于MSC-Exo的治疗方法在预防正畸复发中的应用，为未来致力于改善牙齿稳定性和增强正畸支抗的研究提供新见解。
