Kes Marjolein M G, Berkers Celia R, Drost Jarno
Princess Máxima Center for Pediatric Oncology, Oncode Institute, Utrecht, Netherlands.
Division Cell Biology, Metabolism & Cancer, Department Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.
Front Oncol. 2024 Sep 17;14:1480613. doi: 10.3389/fonc.2024.1480613. eCollection 2024.
Metabolic rewiring is a defining characteristic of cancer cells, driving their ability to proliferate. Leveraging these metabolic vulnerabilities for therapeutic purposes has a long and impactful history, with the advent of antimetabolites marking a significant breakthrough in cancer treatment. Despite this, only a few metabolic discoveries have been successfully translated into effective clinical therapies. This limited translatability is partially due to the use of simplistic models that do not accurately reflect the tumor microenvironment. This Review examines the effects of current cell culture practices on cancer cell metabolism and highlights recent advancements in establishing more physiologically relevant culture conditions and technologies, such as organoids. Applying these improvements may bridge the gap between and findings, facilitating the development of innovative metabolic therapies for cancer.
代谢重编程是癌细胞的一个决定性特征，驱动着它们的增殖能力。利用这些代谢弱点进行治疗有着悠久且具有重大影响的历史，抗代谢物的出现标志着癌症治疗取得了重大突破。尽管如此，只有少数代谢方面的发现成功转化为有效的临床疗法。这种有限的可转化性部分归因于使用了不能准确反映肿瘤微环境的简单模型。本综述探讨了当前细胞培养方法对癌细胞代谢的影响，并强调了在建立更具生理相关性的培养条件和技术（如类器官）方面的最新进展。应用这些改进可能弥合[此处原文缺失两个词]与研究结果之间的差距，促进创新癌症代谢疗法的开发。
