Kłusak Anna, Gazińska Małgorzata Anna
Department of Polymer Engineering and Technology, Faculty of Chemistry, Wrocław University of Science and Technology, Wrocław, Poland.
Front Bioeng Biotechnol. 2024 Sep 17;12:1447340. doi: 10.3389/fbioe.2024.1447340. eCollection 2024.
Poly(glycerol adipate) (PGA) is one of the aliphatic polyesters of glycerol. The most studied biomedical application of poly(glycerol adipate) is the use of its nanoparticles as drug delivery carriers. The PGA prepolymer can be crosslinked to network materials. The biomedical application of PGA-based network materials has largely remained unexplored till recently. The PGA-based network materials, such as poly(glycerol sebacate) elastomers, can be used in soft tissue regeneration due to their mechanical properties. The modulus of elasticity of PGA elastomers is within the range of MPa, which corresponds to the mechanical properties of human soft tissues. This short review aims at briefly summarizing the possible applications of PGA-based elastomers in tissue engineering, as indicated in recent years in research publications.
聚己二酸甘油酯（PGA）是甘油的脂肪族聚酯之一。聚己二酸甘油酯研究最多的生物医学应用是将其纳米颗粒用作药物递送载体。PGA预聚物可以交联成网络材料。直到最近，基于PGA的网络材料的生物医学应用在很大程度上仍未得到探索。基于PGA的网络材料，如聚癸二酸甘油酯弹性体，由于其机械性能可用于软组织再生。PGA弹性体的弹性模量在兆帕范围内，这与人体软组织的机械性能相当。这篇简短的综述旨在简要总结近年来研究出版物中指出的基于PGA的弹性体在组织工程中的可能应用。
