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新型冠状病毒2感染后髓鞘少突胶质细胞糖蛋白相关横贯性脊髓炎：一例报告

Myelin oligodendrocyte glycoprotein-associated transverse myelitis after SARS-CoV-2 infection: A case report.

作者信息

Zheng Jian-Rong, Chang Jun-Lei, Hu Jun, Lin Zhi-Jian, Lin Kai-Hua, Lu Bi-Hua, Chen Xu-Hui, Liu Zhi-Gang

机构信息

Department of Neurology, Peking University Shenzhen Hospital, Shenzhen 518000, Guangdong Province, China.

Department of Neurology, Shenzhen Xinhua Hospital, Shenzhen 518000, Guangdong Province, China.

出版信息

World J Radiol. 2024 Sep 28;16(9):446-452. doi: 10.4329/wjr.v16.i9.446.

DOI:10.4329/wjr.v16.i9.446
PMID:39355395
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11440270/
Abstract

BACKGROUND

Cases of myelin oligodendrocyte glycoprotein (MOG) antibody-related disease have a history of coronavirus disease 2019 infection or its vaccination before disease onset. Severe acute respiratory syndrome virus 2 (SARS-CoV-2) infection has been considered to be a trigger of central nervous system autoimmune diseases.

CASE SUMMARY

Here we report a 20-year male with MOG-associated transverse myelitis after a SARS-CoV-2 infection. The patient received a near-complete recovery after standard immunological treatments.

CONCLUSION

Attention should be paid to the evaluation of typical or atypical neurological symptoms that may be triggered by SARS-CoV-2 infection.

摘要

背景

髓鞘少突胶质细胞糖蛋白（MOG）抗体相关疾病的病例在疾病发作前有新型冠状病毒肺炎感染史或其疫苗接种史。严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染被认为是中枢神经系统自身免疫性疾病的一个触发因素。

病例摘要

在此，我们报告一名20岁男性在感染SARS-CoV-2后发生MOG相关横贯性脊髓炎。该患者在接受标准免疫治疗后几乎完全康复。

结论

应重视对可能由SARS-CoV-2感染引发的典型或非典型神经症状的评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a386/11440270/56abf7dae8fb/WJR-16-446-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a386/11440270/22acf0cbf2b5/WJR-16-446-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a386/11440270/3f2ab8bcd032/WJR-16-446-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a386/11440270/56abf7dae8fb/WJR-16-446-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a386/11440270/22acf0cbf2b5/WJR-16-446-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a386/11440270/3f2ab8bcd032/WJR-16-446-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a386/11440270/56abf7dae8fb/WJR-16-446-g003.jpg

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Neurosci Biobehav Rev. 2024 Sep;164:105792. doi: 10.1016/j.neubiorev.2024.105792. Epub 2024 Jul 3.
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Myelin oligodendrocyte glycoprotein-IgG associated disorders (MOGAD) following SARS-CoV-2 infection: A case series.新冠病毒感染后髓鞘少突胶质细胞糖蛋白抗体相关疾病（MOGAD）：病例系列研究。
J Neuroimmunol. 2022 Sep 15;370:577933. doi: 10.1016/j.jneuroim.2022.577933. Epub 2022 Jul 14.
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MOG encephalomyelitis after vaccination against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2): case report and comprehensive review of the literature.
接种 2019 年冠状病毒病（SARS-CoV-2）疫苗后发生 MOG 脑炎：病例报告及文献综述。
J Neurol. 2022 Oct;269(10):5198-5212. doi: 10.1007/s00415-022-11194-9. Epub 2022 Jun 23.
4
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Neuroimmune disorders in COVID-19.新型冠状病毒肺炎相关神经免疫性疾病。
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