Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
Department of Neurology, Autoimmunity Center of Excellence, University of Michigan Medical Center, MI, USA.
J Neuroimmunol. 2022 Sep 15;370:577933. doi: 10.1016/j.jneuroim.2022.577933. Epub 2022 Jul 14.
This case series describes 9 patients diagnosed with myelin oligodendrocyte glycoprotein (MOG)-IgG associated disorder (MOGAD) following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Patients developed neurological symptoms between 4 days and 5 weeks following SARS-CoV-2 infection. Myelitis was observed in 4 patients; 4 presented with optic neuritis; and encephalopathy was observed in 3. Serum MOG-IgG cell-based assay was medium or high positive in each case. The majority of patients had near-complete recovery following acute immunosuppression. This series adds to the growing number of cases of central nervous system demyelination following SARS-CoV-2 infection and highlights a potential role of infection in the immunopathogenesis of MOGAD.
本病例系列描述了 9 例在严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染后诊断为髓鞘少突胶质细胞糖蛋白（MOG）-IgG 相关疾病（MOGAD）的患者。患者在 SARS-CoV-2 感染后 4 天至 5 周出现神经系统症状。4 例患者出现脊髓炎；4 例患者出现视神经炎；3 例患者出现脑病。在每个病例中，血清 MOG-IgG 基于细胞的检测均为中等或高度阳性。大多数患者在急性免疫抑制后接近完全恢复。本系列增加了 SARS-CoV-2 感染后中枢神经系统脱髓鞘的病例数量，并强调了感染在 MOGAD 的免疫发病机制中的潜在作用。
