Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, 1220 Wire Road, Auburn, Alabama 36849, USA.
Can Vet J. 2024 Oct;65(10):1055-1060.
Tracheal collapse (TC) is an obstructive respiratory disorder in dogs that can affect lifespan and quality of life. Systemic inflammation has been identified in other obstructive airway conditions in dogs and humans. We hypothesized a systemic pro-inflammatory state exists in dogs with TC.
Dogs with TC (TC, = 15) and healthy, non-affected controls (C, = 15), were prospectively enrolled.
Signalment and body condition score (BCS) were recorded for all dogs. For TC dogs, cough duration, pharyngeal collapse, bronchial collapse, and previous stent placement were recorded. Plasma samples were banked at -80°C and batch-analyzed for interleukin-8 (IL-8). Differences between groups were evaluated.
Yorkshire terriers were overrepresented in the TC group. The TC group was older than the C group and had a higher BCS. Interleukin-8 was significantly greater in the TC compared to the C group. Interleukin-8 was not correlated with age sex, BCS, breed, cough duration, pharyngeal collapse, bronchial collapse, or stent placement.
Increased plasma IL-8 concentration supports the presence of systemic inflammation in canine TC. Dogs with TC were older than controls, with a higher BCS, but this did not account for the increased IL-8. Further investigation of IL-8 as a potential biomarker for monitoring TC progression and therapeutic response is warranted.
气管塌陷（TC）是一种影响犬类寿命和生活质量的阻塞性呼吸障碍。在其他犬类和人类的阻塞性气道疾病中已经发现了全身炎症。我们假设 TC 犬存在全身促炎状态。
前瞻性纳入了患有 TC（TC，n=15）和健康、未受影响的对照犬（C，n=15）。
记录所有犬的品种、体况评分（BCS）。对于 TC 犬，记录咳嗽持续时间、咽塌陷、支气管塌陷和先前的支架放置情况。将血浆样本储存在-80°C 下，并进行白细胞介素-8（IL-8）的批量分析。评估组间差异。
约克夏梗在 TC 组中过度表达。TC 组比 C 组年龄更大，BCS 更高。与 C 组相比，TC 组的 IL-8 显著更高。IL-8 与年龄、性别、BCS、品种、咳嗽持续时间、咽塌陷、支气管塌陷或支架放置无关。
血浆中 IL-8 浓度的增加支持犬 TC 存在全身炎症。患有 TC 的犬比对照组年龄更大，BCS 更高，但这并不能解释 IL-8 的增加。进一步研究 IL-8 作为监测 TC 进展和治疗反应的潜在生物标志物是必要的。
