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腹壁裂开:发展中国家严重孕产妇发病的可预防风险(坦桑尼亚一家大学教学医院的病例对照研究)

Burst abdomen: a preventable risk of severe maternal morbidity in a developing country (a case-control study at a university teaching hospital in Tanzania).

作者信息

Mgaya Andrew Hans, Maumba Salim Alli, Mapunda Bosco Pius, Kiwango Sophia Isaac, Kiponza Raymond Thomas, Mtinangi Nathanael Luther

机构信息

Department of Obstetrics and Gynaecology, Muhimbili National Hospital, PO Box 65000, Dar es Salaam, Tanzania.

Department of Women´s and Children´s Health/International Maternal and Reproductive Health and Migration, Uppsala University, Uppsala, Sweden.

出版信息

Pan Afr Med J. 2024 Jun 19;48:64. doi: 10.11604/pamj.2024.48.64.39044. eCollection 2024.

Abstract

INTRODUCTION

burst abdomen is a preventable complication of caesarean section that carries an increased risk of maternal death, especially in developing countries including Tanzania. The study aimed to identify the risk factors and high-risk patients for burst abdomen at Muhimbili National Hospital in Tanzania.

METHODS

a case-control study was performed at Muhimbili National Hospital in Dar es Salaam from 2 April to 27 December 2019. Characteristics of interest of one case of burst abdomen were compared to three randomly selected controls that consisted of caesarean deliveries either 24 hours before or after the time of delivery of cases. The chi-square test, Fischer´s exact test, and multivariate analysis were used. The level of significance was p < 0.05.

RESULTS

a total of 524 women that met the inclusion criteria, comprising 131 cases and 393 controls, delivered by caesarean section in the most recent pregnancy at Muhimbili National Hospital. Cases were independently associated with perioperative illness, including cough (OR 3.8, 95%CI 1.9-7.6), chorioamnionitis (OR 4.5, 95% CI 1.3-14.7), and surgical site infection (OR 3.2, 95% CI 1.7-6.4), and a vertical midline incision wound (OR 1.9, 95% CI 1.2-3.1) compared to control group. Most cases (70%) had intact sutures and loose surgical knots.

CONCLUSION

burst abdomen remains a cause of unnecessary severe maternal morbidity and is independently associated with perioperative illnesses such as cough, chorioamnionitis surgical site infection, and a vertical midline abdominal incision. Thus, there is a need for modifying abdominal fascia closure techniques for patients at risk.

摘要

引言

剖腹产后腹壁裂开是一种可预防的并发症,会增加产妇死亡风险,在包括坦桑尼亚在内的发展中国家尤为如此。本研究旨在确定坦桑尼亚穆希姆比利国家医院剖腹产后腹壁裂开的风险因素和高危患者。

方法

2019年4月2日至12月27日在达累斯萨拉姆的穆希姆比利国家医院进行了一项病例对照研究。将1例剖腹产后腹壁裂开病例的相关特征与3例随机选择的对照进行比较,对照组为病例分娩时间前后24小时内进行剖宫产的产妇。采用卡方检验、费舍尔精确检验和多变量分析。显著性水平为p<0.05。

结果

共有524名符合纳入标准的女性在穆希姆比利国家医院最近一次妊娠时接受了剖宫产,其中包括131例病例和393例对照。病例与围手术期疾病独立相关,包括咳嗽(比值比3.8,95%置信区间1.9-7.6)、绒毛膜羊膜炎(比值比4.5,95%置信区间1.3-14.7)和手术部位感染(比值比3.2,95%置信区间1.7-6.4),与对照组相比,垂直中线切口伤口(比值比1.9,95%置信区间1.2-3.1)也与之相关。大多数病例(70%)缝线完整但手术结松弛。

结论

剖腹产后腹壁裂开仍然是导致不必要的严重产妇发病的原因,并且与围手术期疾病如咳嗽、绒毛膜羊膜炎、手术部位感染以及垂直中线腹部切口独立相关。因此,有必要为高危患者改进腹壁筋膜闭合技术。

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