McIntyre Emma, Lamb Philina, Fung Maxwell A, Kiuru Maija, Chan Lawrence S
Department of Dermatology UC-Davis School of Medicine Sacramento California USA.
Skin Health Dis. 2024 Jul 24;4(5):e412. doi: 10.1002/ski2.412. eCollection 2024 Oct.
The COVID-19 pandemic brought not only a huge healthcare challenge to the world but also introduced many questions of how the human immune system reacts to counter viral invasion, including vaccination. Unlike most vaccinations that are not usually linked to any specific skin eruptions, COVID-19 vaccination has been linked to a variety of skin lesions. In this paper, we present two patients who developed granulomatous skin lesions post-COVID-19 vaccination, one patient has generalised granuloma annulare (GA) and the other patient develops localised GA. Both patients have good responses to treatment regimens containing systemic corticosteroids. We review the literature pertaining to COVID-19-linked skin diseases, particularly granulomatous diseases and discuss the possible pathomechanism of granulomatous eruptions in relation to COVID-19 vaccination.
新冠疫情不仅给全球带来了巨大的医疗挑战，还引发了许多关于人类免疫系统如何应对病毒入侵（包括疫苗接种）的问题。与大多数通常与任何特定皮肤疹无关的疫苗接种不同，新冠疫苗接种与多种皮肤病变有关。在本文中，我们介绍了两名在接种新冠疫苗后出现肉芽肿性皮肤病变的患者，一名患者患有泛发性环状肉芽肿（GA），另一名患者患有局限性GA。两名患者对含全身用皮质类固醇的治疗方案均有良好反应。我们回顾了与新冠相关皮肤病，特别是肉芽肿性疾病相关的文献，并讨论了与新冠疫苗接种相关的肉芽肿性皮疹的可能发病机制。
