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一例与高嗜酸性粒细胞综合征相关的嗜酸性毛囊炎和嗜酸性蜂窝织炎混合病例。

A hybrid case of eosinophilic folliculitis and eosinophilic cellulitis associated with hypereosinophilic syndrome.

作者信息

Iatropoulou Domniki, Sprenger Cathryn, Griffiths Richard, Wijesuriya Nilukshi, Ho Bernard

机构信息

Department of Dermatology St George's University Hospitals NHS Foundation Trust London UK.

Department of Pathology St George's Hospital NHS Foundation Trust London UK.

出版信息

Skin Health Dis. 2024 Jun 16;4(5):e407. doi: 10.1002/ski2.407. eCollection 2024 Oct.

DOI:10.1002/ski2.407
PMID:39355749
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11442077/
Abstract

Eosinophilic cellulitis or Wells syndrome encompasses distinct histopathological features but can also be associated with eosinophilic related conditions like hyper eosinophilic syndrome (HES) or eosinophilic granulomatosis with polyangiitis (EGPA) (Churg-Strauss syndrome). We report a case of a Turkish 41-year-old female who presented in clinic with pruritus and tenderness on her chest and breasts, having received several courses of antibiotics for recurrent abscess formation. A year before she had been diagnosed with HES with multiorgan involvement that included biopsy proven eosinophilic folliculitis, and prompted further investigation including bone marrow aspiration that revealed T cell clonality. Biopsy of her rash revealed eosinophilic infiltration of the dermis with flame figures. Ongoing respiratory symptoms and a history of childhood asthma were suggestive of EGPA. This case highlights important associations that should be considered in the investigation of Wells syndrome.

摘要

嗜酸性粒细胞性蜂窝织炎或韦尔斯综合征具有独特的组织病理学特征，但也可能与嗜酸性粒细胞相关疾病有关，如高嗜酸性粒细胞综合征（HES）或嗜酸性肉芽肿性多血管炎（EGPA）（变应性肉芽肿性血管炎）。我们报告了一例41岁的土耳其女性病例，该患者因胸部和乳房瘙痒及压痛前来就诊，此前因反复形成脓肿接受了多个疗程的抗生素治疗。一年前，她被诊断为多器官受累的HES，包括活检证实的嗜酸性粒细胞性毛囊炎，并促使进行了包括骨髓穿刺在内的进一步检查，结果显示T细胞克隆性。对其皮疹进行活检显示真皮有嗜酸性粒细胞浸润，并伴有火焰状图形。持续的呼吸道症状和儿童哮喘病史提示可能患有EGPA。该病例突出了在韦尔斯综合征调查中应考虑的重要关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf37/11442077/8204332f78ef/SKI2-4-e407-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf37/11442077/382a01d86d93/SKI2-4-e407-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf37/11442077/f0806131ede9/SKI2-4-e407-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf37/11442077/52b409ab1d1e/SKI2-4-e407-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf37/11442077/a1ec9ab49684/SKI2-4-e407-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf37/11442077/8204332f78ef/SKI2-4-e407-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf37/11442077/382a01d86d93/SKI2-4-e407-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf37/11442077/f0806131ede9/SKI2-4-e407-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf37/11442077/52b409ab1d1e/SKI2-4-e407-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf37/11442077/a1ec9ab49684/SKI2-4-e407-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf37/11442077/8204332f78ef/SKI2-4-e407-g006.jpg

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