Juramy Marie, Besson Eric, Gastaldi Stéphane, Ziarelli Fabio, Viel Stéphane, Mollica Giulia, Thureau Pierre
Aix-Marseille Univ., CNRS, ICR UMR 7273, 13397 Marseille, France.
Aix-Marseille Univ., Centrale Mediterranée, CNRS, Fédération des Sciences Chimiques FR 1739, 13397 Marseille, France.
Faraday Discuss. 2025 Jan 8;255(0):483-494. doi: 10.1039/d4fd00123k.
In this study, nuclear magnetic resonance (NMR) is used to investigate the crystallisation behaviour of aspirin within a mesoporous SBA-15 silica material. The potential of dynamic nuclear polarisation (DNP) experiments is also investigated using specifically designed porous materials that incorporate polarising agents within their walls. The formation of the metastable crystalline form II is observed when crystallisation occurs within the pores of the mesoporous structure. Conversely, bulk crystallisation yields the most stable form, namely form I, of aspirin. Remarkably, the metastable form II remains trapped within the pores of mesoporous SBA-15 silica material even 30 days after impregnation, underscoring its persistent stability within this confined environment.
在本研究中，核磁共振（NMR）用于研究阿司匹林在介孔SBA - 15二氧化硅材料中的结晶行为。还使用了在其壁内掺入极化剂的特殊设计的多孔材料来研究动态核极化（DNP）实验的潜力。当在介孔结构的孔内发生结晶时，会观察到亚稳晶型II的形成。相反，本体结晶产生阿司匹林最稳定的晶型，即晶型I。值得注意的是，即使在浸渍30天后，亚稳晶型II仍被困在介孔SBA - 15二氧化硅材料的孔内，这突出了其在这种受限环境中的持久稳定性。
