Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People's Republic of China.
J Nat Prod. 2024 Oct 25;87(10):2408-2420. doi: 10.1021/acs.jnatprod.4c00658. Epub 2024 Oct 2.
Fourteen previously undescribed sesterterpenoids (-) were isolated from . Their structures with absolute configurations were elucidated by NMR, HRESIMS, DP4+ calculations, ECD calculations, single-crystal X-ray diffraction analyses, and the modified Mosher's method. Compounds - possess an uncommon 5/11 bicyclic ring system identified from for the first time. Compounds - have a 5/8/5 tricyclic ring system, and these compounds both possess carbonyl groups in ring A. Compound showed significant reversal of paclitaxel resistance in cancer cells.
从 中分离得到 14 个以前未描述过的倍半萜 (-)。通过 NMR、HRESIMS、DP4+ 计算、ECD 计算、单晶 X 射线衍射分析和改进的 Mosher 法确定了它们的结构和绝对构型。化合物 - 拥有一个首次从 中鉴定出的不常见的 5/11 双环系统。化合物 - 具有 5/8/5 三环系统，这两种化合物在环 A 中都含有羰基。化合物 在癌细胞中显示出显著逆转紫杉醇耐药性的作用。
