Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, (Heilongjiang University of Chinese Medicine), 150040, Harbin, People's Republic of China.
Institute of Nature and Ecology, Heilongjiang Academy of Sciences, 150040, Harbin, People's Republic of China.
J Nat Med. 2024 Jun;78(3):702-708. doi: 10.1007/s11418-024-01793-3. Epub 2024 Apr 25.
Two new sesterterpenoids, atractylodes japonica terpenoid acid I (1) and atractylodes japonica terpenoid aldehyde I (2), were isolated from the rhizomes of Atractylodes japonica Koidz. ex Kitam together with ten known compounds (3-12). Their structures were elucidated on the basis of comprehensive spectroscopic analysis (1D/2D NMR, HRESIMS and IR). In addition, all of these isolated compounds were evaluated for their cytotoxic activities against human gastric cancer cell MGC-803 and human hepatocellular cancer cell HepG-2. Most of them exhibited moderate to weak inhibitory effects with IC values in the range of 25.15-88.85 μM except for 9-12.
从白术的根茎中分离得到了两种新的倍半萜类化合物，白术萜酸 I（1）和白术萜醛 I（2），以及另外 10 种已知化合物（3-12）。基于全面的光谱分析（1D/2D NMR、HRESIMS 和 IR）确定了它们的结构。此外，还评估了所有这些分离得到的化合物对人胃癌细胞 MGC-803 和人肝癌细胞 HepG-2 的细胞毒性活性。除了 9-12 之外，大多数化合物都表现出中等至较弱的抑制作用，IC 值范围为 25.15-88.85 μM。
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