调节 T 辅助 2 细胞分化和功能的分子机制。

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.

Curr Opin Immunol. 2024 Dec;91:102483. doi: 10.1016/j.coi.2024.102483. Epub 2024 Oct 1.

T helper 2 (T2) cells orchestrate type 2 immunity during protective antihelminth immunity and help restore tissue homoeostasis. Their misdirected activities against innocuous substances also underlie atopic diseases, such as asthma and allergy. Recent technological advances are uncovering novel insights into the molecular mechanisms governing T2 cell differentiation and function.

辅助性 T 细胞 2（T2）细胞在保护性抗寄生虫免疫过程中协调 2 型免疫，并有助于恢复组织内稳态。它们针对无害物质的不当活性也是特应性疾病（如哮喘和过敏）的基础。最近的技术进步揭示了调控 T2 细胞分化和功能的分子机制的新见解。