Immunoregulation and Infection Laboratory, The Francis Crick Institute, London, United Kingdom.
i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.
Curr Opin Immunol. 2024 Dec;91:102495. doi: 10.1016/j.coi.2024.102495. Epub 2024 Oct 1.
Intricate immune regulation is required at mucosal surfaces to allow tolerance to microbiota and harmless allergens and to prevent overexuberant inflammatory responses to pathogens. The cytokine Interleukin-10 (IL-10) is a key mediator of mucosal immune regulation. While IL-10 can be produced by virtually all cells of the immune system, many of its in vivo functions depend upon its production by regulatory or effector T cell populations and its signalling to macrophages, dendritic cells and specific T cell subsets. In this review, we discuss our current understanding of the role of IL-10 in regulation of immune responses, with a focus on its context-specific roles in intestinal homeostasis, respiratory infection and asthma. We highlight the importance of appropriate production and function of IL-10 for balancing pathogen clearance, control of microbiota and host tissue damage, and that precise modulation of IL-10 functions in vivo could present therapeutic opportunities.
黏膜表面需要精细的免疫调节，以允许对微生物群和无害过敏原的耐受，并防止对病原体产生过度活跃的炎症反应。细胞因子白细胞介素-10 (IL-10) 是黏膜免疫调节的关键介质。虽然 IL-10 几乎可以由免疫系统的所有细胞产生，但它的许多体内功能取决于其由调节性或效应 T 细胞群产生及其向巨噬细胞、树突状细胞和特定 T 细胞亚群的信号传导。在这篇综述中，我们讨论了我们目前对 IL-10 在免疫反应调节中的作用的理解，重点讨论了其在肠道稳态、呼吸道感染和哮喘中的特定作用。我们强调了适当产生和发挥 IL-10 的重要性，以平衡病原体清除、控制微生物群和宿主组织损伤，并且体内精确调节 IL-10 功能可能会提供治疗机会。
