抗癫痫药物治疗部分性发作和强直阵挛性发作的比较疗效
The comparative efficacy of antiepileptic drugs for partial and tonic-clonic seizures.
作者信息
Chadwick D, Turnbull D M
出版信息
J Neurol Neurosurg Psychiatry. 1985 Nov;48(11):1073-7. doi: 10.1136/jnnp.48.11.1073.
Abstract
Studies of the efficacy of anticonvulsant drugs are difficult to undertake and historically have been of poor quality. Randomised comparisons of drugs are few in number, and have failed to detect significant differences between drugs. This is surprising in view of the strong feelings that many clinicians have about the relative efficacy of the drugs they use. A review of the literature emphasises the need for further studies in this field.
摘要
抗惊厥药物疗效的研究很难开展，而且从历史上看质量都不高。药物的随机对照比较数量很少，并且未能发现不同药物之间的显著差异。鉴于许多临床医生对他们所使用药物的相对疗效有着强烈的看法，这一结果令人惊讶。文献综述强调了该领域进一步研究的必要性。
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The comparative efficacy of antiepileptic drugs for partial and tonic-clonic seizures.抗癫痫药物治疗部分性发作和强直阵挛性发作的比较疗效
J Neurol Neurosurg Psychiatry. 1985 Nov;48(11):1073-7. doi: 10.1136/jnnp.48.11.1073.
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A comparative study of progabide, valproate, and placebo as add-on therapy in patients with refractory epilepsy.丙戊酸、加巴喷丁与安慰剂作为难治性癫痫附加治疗的比较研究。
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本文引用的文献
1
Comparative results in seizure control using phenobarbital, dilantin, and mesantoin.使用苯巴比妥、苯妥英钠和美索因控制癫痫发作的对比结果。
Am J Psychiatry. 1950 Dec;107(6):415-21. doi: 10.1176/ajp.107.6.415.
2
Comparison of the effectiveness of phenobarital, mephobarbital, primidone, diphenylhydantoin, ethotoin, metharbital, and methylphenylethylhydantoin in motor seizures.苯巴比妥、甲巴比妥、扑米酮、苯妥英、乙苯妥英、甲乙巴比妥及甲苯乙妥因对运动性癫痫发作疗效的比较
Clin Pharmacol Ther. 1962 Jan-Feb;3:23-8. doi: 10.1002/cpt19623123.
3
Clonazepam (Rivotril) and carbamazepine (Tegretol) in psychomotor epilepsy: a randomized multicenter trial.氯硝西泮（利必通）和卡马西平（得理多）治疗精神运动性癫痫：一项随机多中心试验。
Epilepsia. 1981 Aug;22(4):415-20. doi: 10.1111/j.1528-1157.1981.tb06152.x.
4
Two antiepileptic drugs for intractable epilepsy with complex-partial seizures.两种用于治疗伴有复杂部分性发作的顽固性癫痫的抗癫痫药物。
J Neurol Neurosurg Psychiatry. 1982 Dec;45(12):1119-24. doi: 10.1136/jnnp.45.12.1119.
5
A comparison of phenytoin and pheneturide in patients with epilepsy: a double-blind cross-over trial.癫痫患者中苯妥英钠与苯乙妥因的比较：一项双盲交叉试验。
J Neurol Neurosurg Psychiatry. 1982 Dec;45(12):1113-8. doi: 10.1136/jnnp.45.12.1113.
6
Early prognosis of epilepsy.癫痫的早期预后
Br Med J (Clin Res Ed). 1982 Dec 11;285(6356):1699-701. doi: 10.1136/bmj.285.6356.1699.
7
Controlled trials in epilepsy: a review.癫痫的对照试验：综述
Epilepsia. 1982 Oct;23(5):491-519. doi: 10.1111/j.1528-1157.1982.tb05437.x.
8
Comparison of sodium valproate and phenytoin as single drug treatment in epilepsy.丙戊酸钠与苯妥英钠作为癫痫单药治疗的比较。
Epilepsia. 1981 Feb;22(1):27-33. doi: 10.1111/j.1528-1157.1981.tb04330.x.
9
[Efficacy of sodium valproate in partial epilepsy. Crossed study of valproate and carbamazepine].丙戊酸钠治疗部分性癫痫的疗效。丙戊酸钠与卡马西平的交叉研究
Rev Neurol (Paris). 1984;140(6-7):434-7.
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