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超越传统抗生素方法:全球视角下的替代疗法,包括草药预防和牛乳腺炎的主动管理策略。

Beyond conventional antibiotics approaches: Global perspectives on alternative therapeutics including herbal prevention, and proactive management strategies in bovine mastitis.

机构信息

Centre for Medical Biotechnology, Maharshi Dayanand University, Rohtak, India.

Department of Microbiology, Maharshi Dayanand University, Rohtak, India.

出版信息

Microb Pathog. 2024 Nov;196:106989. doi: 10.1016/j.micpath.2024.106989. Epub 2024 Sep 30.

Abstract

Mastitis, an intramammary inflammation resulting from microbial infectious agents, continues to pose a significant challenge within the dairy sector, adversely affecting animal well-being and leading to substantial economic losses. These losses are attributed to decreased milk production, heightened culling rates, and the expenses related to diagnostics, veterinary care, medication, and labor. Moreover, additional costs emerge due to reduced forthcoming milk yields, compromised reproductive health, and increased susceptibility to various illnesses. Identifying the responsible agents is crucial for disease management and the implementation of antimicrobial treatments. Despite the prevalent use of antibiotic treatment, the pressing need for new therapeutic alternatives to combat bovine mastitis arises from limitations, including low cure rates, rising resistance, and the presence of antibiotic residues in milk. This review explores the potential application of herbal extracts and essential oils known for their antimicrobial properties as alternative options for managing pathogens in mastitis treatment. It examines various treatment methods and management strategies, particularly emphasizing the progress of herbal remedies and natural therapeutics in addressing mastitis, a significant concern in bovine populations and dairy herds.

摘要

乳腺炎是一种由微生物感染引起的乳腺内炎症,继续给奶牛养殖业带来重大挑战,严重影响动物福利,并导致巨大的经济损失。这些损失归因于产奶量下降、淘汰率上升,以及与诊断、兽医护理、药物和劳动力相关的费用。此外,由于未来产奶量减少、生殖健康受损以及更容易感染各种疾病,还会产生额外的成本。确定致病因子对于疾病管理和抗菌治疗的实施至关重要。尽管普遍使用抗生素治疗,但由于治愈率低、耐药性上升以及牛奶中存在抗生素残留等限制,迫切需要新的治疗替代品来对抗牛乳腺炎。本综述探讨了具有抗菌特性的草药提取物和精油作为治疗乳腺炎中病原体的替代选择的潜在应用。它检查了各种治疗方法和管理策略,特别强调了草药疗法和自然疗法在解决乳腺炎方面的进展,乳腺炎是奶牛群和奶牛场的一个重大问题。

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