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一种用于识别择期开放性腹主动脉瘤修复术后非回家出院高风险患者的新型术前风险评分。

A Novel Preoperative Risk Score to Identify Patients at High Risk for Nonhome Discharge after Elective Open Abdominal Aortic Aneurysm Repair.

作者信息

Ramirez Joel L, Sung Eric, Gasper Warren J, Conte Michael S, Boitano Laura T, Ulloa Jesus G, Iannuzzi James C

机构信息

Division of Vascular and Endovascular Surgery, Department of Surgery, University of California, San Francisco, San Francisco, CA.

Division of Vascular and Endovascular Surgery, Department of Surgery, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.

出版信息

Ann Vasc Surg. 2025 Jan;110(Pt A):265-273. doi: 10.1016/j.avsg.2024.08.007. Epub 2024 Sep 30.

Abstract

BACKGROUND

Nonhome discharge (NHD) to a rehabilitation or skilled nursing facility after vascular surgery is poorly described despite its impact on patients. For home-dwelling patients undergoing elective surgery, the need for postoperative NHD can have meaningful implications on quality of life, long-term outcomes, and health-care spending. Understanding postsurgical NHD risk is essential to preoperative counseling and shared decision making. This is particularly true for the treatment of abdominal aortic aneurysms (AAAs) as the postoperative course can vary between open and endovascular surgery. We aimed to identify independent predictors of NHD following elective open abdominal aortic aneurysm repair (OAR), and to create a clinically useful preoperative risk score.

METHODS

Elective OAR cases were queried from the Society for Vascular Surgery Vascular Quality Initiative from years 2013-2022. A risk score was created by splitting the data set into two-thirds for development and one-third for validation. A parsimonious stepwise hierarchical multivariable logistic regression controlling for hospital level variation was performed in the development dataset, and the beta-coefficients were used to assign points for a risk score. The score was then validated, and model performance assessed.

RESULTS

Overall, 8,274 patients were included and 1,502 (18.2%) required NHD. At baseline, patients who required NHD were more likely to be ≥ 80 years old (23.6% vs. 6.5%), female (35.9% vs. 23.1%), not independently ambulatory (14.6% vs. 4.3%), anemic (24.4% vs. 13.9%), have chronic obstructive pulmonary disease (COPD, 41.6% vs. 30.7%), American Society of Anesthesiologists (ASA) class ≥4 (41.0% vs. 32.5%), and a supraceliac proximal clamp (9.8% vs. 5.7%; all P < 0.05). Multivariable analysis in the development group identified the following independent predictors of NHD: age ≥80 years, not independently ambulatory, proximal clamp location, hypogastric artery occlusion, anemia (Hb < 12 g/dL), COPD, female sex, hypertension, and ASA class ≥4. These were then used to create a 14-point risk score. Patients were stratified into three groups based upon their risk score: low risk (0-4 points; n = 4,966) with an NHD rate of 9.9%, moderate risk (5-6 points; n = 2,442) with an NHD rate of 25.5%, and high risk (≥7 points; n = 886) with an NHD rate of 44.6%. The risk score had good predictive ability with c-statistic = 0.73 for model development and c-statistic = 0.72 in the validation dataset.

CONCLUSIONS

This novel risk score can predict NHD following elective OAR using characteristics that can be identified preoperatively. Utilization of this score may allow for improved risk assessment, preoperative counseling, and shared decision making.

摘要

背景

血管手术后转至康复机构或专业护理机构的非居家出院情况虽对患者有影响,但相关描述较少。对于接受择期手术的居家患者而言,术后非居家出院的需求可能对生活质量、长期预后及医疗支出产生重大影响。了解术后非居家出院风险对于术前咨询和共同决策至关重要。在腹主动脉瘤(AAA)治疗中尤其如此,因为开放手术和血管内手术的术后病程有所不同。我们旨在确定择期开放性腹主动脉瘤修复术(OAR)后非居家出院的独立预测因素,并创建一个具有临床实用性的术前风险评分。

方法

从血管外科学会血管质量改进项目中查询2013年至2022年的择期OAR病例。通过将数据集分为三分之二用于模型构建和三分之一用于验证来创建风险评分。在构建数据集中进行控制医院水平差异的简约逐步分层多变量逻辑回归分析,并使用β系数为风险评分赋值。然后对该评分进行验证,并评估模型性能。

结果

总体而言,共纳入8274例患者,其中1502例(18.2%)需要非居家出院。在基线时,需要非居家出院的患者更可能年龄≥80岁(23.6%对6.5%)、为女性(35.9%对23.1%)、不能独立行走(14.6%对4.3%)、贫血(24.4%对13.9%)、患有慢性阻塞性肺疾病(COPD,41.6%对30.7%)、美国麻醉医师协会(ASA)分级≥4级(41.0%对32.5%)以及使用腹腔干上方近端阻断钳(9.8%对5.7%;所有P<0.05)。构建组的多变量分析确定了以下非居家出院的独立预测因素:年龄≥80岁、不能独立行走、近端阻断钳位置、下腹动脉闭塞、贫血(血红蛋白<12g/dL)、COPD、女性、高血压以及ASA分级≥4级。然后用这些因素创建了一个14分的风险评分。根据风险评分将患者分为三组:低风险(0 - 4分;n = 4966),非居家出院率为9.9%;中度风险(5 - 6分;n = 2442),非居家出院率为25.5%;高风险(≥7分;n = 886),非居家出院率为44.6%。该风险评分具有良好的预测能力,模型构建时的c统计量为0.73,验证数据集中的c统计量为0.72。

结论

这个新的风险评分可以利用术前可识别的特征来预测择期OAR后的非居家出院情况。使用该评分可能有助于改善风险评估、术前咨询和共同决策。

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