Department of Primary Care and Population Health, University College London, London, UK
Department of Primary Care and Population Health, University College London, London, UK.
Occup Environ Med. 2024 Oct 8;81(9):471-479. doi: 10.1136/oemed-2024-109621.
The objectives of this study were to examine post COVID-19 syndrome (PCS) among healthcare workers (HCWs) in England and explore risk factors for the condition.
Data were collected by National Health Service (NHS) CHECK, a longitudinal study exploring HCWs' mental and physical well-being during and after the COVID-19 pandemic. NHS CHECK collected data at four timepoints: the baseline survey between April 2020 and January 2021, and then three follow-up surveys at approximately 6, 12 and 32 months post baseline. PCS data were collected at 12 and 32 months, while risk factor data were from baseline. HCWs were asked what COVID-19 symptoms they experienced and for how long and were classified as having PCS if they had any symptom for ≥12 weeks. Multilevel regressions were used to examine risk factors for PCS.
This study included 5248 HCWs. While 33.6% (n=1730) reported prolonged COVID-19 symptoms consistent with PCS, only 7.4% (n=385) reported a formal diagnosis of PCS. Fatigue, difficult concentrating, insomnia and anxiety or depression were the most common PCS symptoms. Baseline risk factors for reporting PCS included screening for common mental disorders, direct contact with COVID-19 patients, pre-existing respiratory illnesses, female sex and older age.
While a third of HCWs reported prolonged COVID-19 symptoms consistent with PCS, a smaller percentage reported a formal diagnosis of the condition. We replicate findings that direct contact with COVID-19 patients, older age, female sex, pre-existing respiratory illness and symptoms of common mental disorders are associated with increased risk of PCS.
本研究旨在调查英格兰医护人员（HCWs）的新冠后综合征（PCS），并探讨其发病的危险因素。
本研究数据来源于英国国家医疗服务体系（NHS）的 CHECK 研究，该研究旨在探索新冠大流行期间和之后 HCWs 的身心健康状况。NHS CHECK 通过四次调查收集数据：2020 年 4 月至 2021 年 1 月的基线调查，以及基线后约 6、12 和 32 个月的三次随访调查。PCS 数据在 12 个月和 32 个月时收集，而危险因素数据来自基线。如果 HCW 报告有任何症状持续 12 周以上，则将其归类为患有 PCS，并询问其 COVID-19 症状及持续时间。采用多水平回归分析方法来研究 PCS 的发病危险因素。
本研究共纳入 5248 名 HCWs。虽然 33.6%（n=1730）报告了持续时间≥12 周的 COVID-19 症状，符合 PCS 表现，但仅有 7.4%（n=385）报告了正式的 PCS 诊断。疲劳、难以集中注意力、失眠、焦虑或抑郁是最常见的 PCS 症状。报告发生 PCS 的基线危险因素包括常见精神障碍筛查、与 COVID-19 患者直接接触、既往呼吸系统疾病、女性和年龄较大。
尽管三分之一的 HCWs 报告了持续时间≥12 周的 COVID-19 症状，符合 PCS 表现，但只有一小部分报告了该疾病的正式诊断。我们发现与 COVID-19 患者直接接触、年龄较大、女性、既往呼吸系统疾病和常见精神障碍症状与 PCS 发病风险增加相关，这一结果与既往研究一致。
