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长新冠在医护人员中的情况:定义、流行率、症状、风险因素和影响的叙述性综述。

Long COVID among healthcare workers: a narrative review of definitions, prevalence, symptoms, risk factors and impacts.

机构信息

Department of Primary Care and Population Health, University College London, 1-19 Torrington Place, London, WC1E 7HB, UK.

Guy's and St Thomas NHS Foundation Trust, St Thomas' Education Centre, 75-79 York Road, London, SE1 7NJ, UK.

出版信息

Br Med Bull. 2024 Sep 27;151(1):16-35. doi: 10.1093/bmb/ldae008.

Abstract

INTRODUCTION

Long COVID (LC) occurs when people experience symptoms for weeks, months or even years after a COVID-19 infection. This review looks at research exploring the LC definitions, prevalence, symptoms, risk factors, and associated impacts in research on healthcare workers (HCWs).

DATA SOURCES

We systematically searched five electronic databases (CINAHL, EMBASE, Medline, PsycInfo and PubMed) and compiled a narrative literature review based on 56 relevant studies.

AREAS OF AGREEMENT

LC is prevalent among HCWs who become infected by COVID-19. Many of the most frequent symptoms associated with LC in the general population are also reported among HCWs. Some risk factors for LC are also similar to those in the general population, such as female sex, older age, and having a pre-existing respiratory illness.

AREAS OF CONTROVERSY

The mechanism(s) responsible for LC remains unknown. A variety of terms, timeframes and symptoms are used to define LC, creating difficulties in comparing results across studies. Much of the research is cross-sectional and fails to explore the impacts that prolonged symptoms have on HCWs' personal and professional lives.

GROWING POINTS

The need to support HCWs with LC is clear. Identifying the mechanism(s) responsible for LC is a key priority, as this will inform treatments.

AREAS FOR DEVELOPING RESEARCH

Future research should move towards a standard definition for LC. Greater attention should be paid to longitudinal and qualitative studies, which could give insights into prognosis, lived experience and work participation. Finally, studies evaluating treatments suitable for people with LC are timely.

摘要

简介

长新冠(LC)是指在 COVID-19 感染后数周、数月甚至数年仍出现症状的情况。本综述着眼于研究探索 LC 的定义、流行率、症状、危险因素以及医护人员(HCWs)中相关影响的研究。

资料来源

我们系统地搜索了五个电子数据库(CINAHL、EMBASE、Medline、PsycInfo 和 PubMed),并根据 56 项相关研究编写了叙述性文献综述。

共识领域

LC 在感染 COVID-19 的 HCWs 中很常见。在普通人群中与 LC 相关的许多最常见症状也在 HCWs 中报告。LC 的一些危险因素也与普通人群相似,例如女性、年龄较大和患有先前存在的呼吸系统疾病。

争议领域

导致 LC 的机制尚不清楚。用于定义 LC 的各种术语、时间框架和症状造成了在研究间比较结果的困难。大部分研究都是横断面的,未能探讨长期症状对 HCWs 个人和职业生活的影响。

研究进展

支持 LC 患者的需求是明确的。确定导致 LC 的机制是当务之急,因为这将为治疗提供信息。

研究发展领域

未来的研究应该朝着 LC 的标准定义方向发展。应更加关注纵向和定性研究,这可以深入了解预后、生活体验和工作参与度。最后,评估适合 LC 患者的治疗方法的研究是及时的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aae/11436955/dd262ac6120f/ldae008f1.jpg

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