Tsuruta Y, Sato T, Miyahara H, Yoshino K, Umatani K
Gan No Rinsho. 1985 Oct;31(13):1717-20.
A 53-year-old man under a diagnosis of piriform sinus carcinoma T 3 N 1 was treated with neoadjuvant chemotherapy consisting of cisplatin (70 mg/m2) and peplomycin (5 mg/day X 10), followed by radical neck dissection and radiotherapy to the primary site and whole neck. After two courses of chemotherapy, the primary tumor showed complete response and nodal metastasis showed partial response. After discharge, the patient has shown no evidence of disease. Hypopharyngeal carcinoma was controlled with neoadjuvant chemotherapy and radiotherapy without the patient's voice being lost, since chemotherapy as the initial treatment was very effective in reduction of the tumor bulk and did not damage the blood circulation.
