Freeman R B, Marks J E, Ogura J H
Laryngoscope. 1979 Nov;89(11):1855-63. doi: 10.1288/00005537-197911000-00021.
A retrospective analysis of 175 patients having a histopathologic diagnosis of epidermoid carcinoma of the pyriform sinus presenting between January 1, 1964 and December 31, 1973 was undertaken to establish the effectiveness of conservation surgery in preserving voice. Patients were treated by three separate methods: 1. preoperative radiation therapy, partial laryngopharyngectomy and radical neck dissection (PLP and RND) (N = 85); 2. preoperative radiation therapy, total laryngopharyngectomy and radical neck dissection (TLP and RND), (N = 57); and 3. palliation, which consisted of palliative radiation therapy alone or combinations of radiation therapy and chemotherapy or palliative surgery (N = 33). Of the 85 patients treated with the expectation of cancer cure and voice preservation (PLP and RND), 44 or 52% actually had their voice preserved. Of course, in none of the patients treated by TLP and RND was voice preserved, but 2 of the 33 patients treated palliatively retained ability to speak. Overall, 46 of 175 patients (26%) with carcinoma of the pyriform sinus were afforded voice preservation. The ability to preserve voice is correlated with stage and an analysis of operative complications is presented.
对1964年1月1日至1973年12月31日期间经组织病理学诊断为梨状窦表皮样癌的175例患者进行回顾性分析，以确定保留手术在保留嗓音方面的有效性。患者采用三种不同方法治疗：1. 术前放射治疗、部分喉咽切除术和根治性颈清扫术（PLP和RND）（N = 85）；2. 术前放射治疗、全喉咽切除术和根治性颈清扫术（TLP和RND）（N = 57）；3. 姑息治疗，包括单纯姑息性放射治疗或放射治疗与化疗联合或姑息性手术（N = 33）。在预期可治愈癌症并保留嗓音的85例接受PLP和RND治疗的患者中，44例（52%）实际上保留了嗓音。当然，接受TLP和RND治疗的患者无一保留嗓音，但接受姑息治疗的33例患者中有2例仍保留说话能力。总体而言，175例梨状窦癌患者中有46例（26%）得以保留嗓音。保留嗓音的能力与分期相关，并对手术并发症进行了分析。
