Pan Yuan, Zhou Yantao, Shi Xianghua, He Suifen, Lai Weibo
Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510260, P.R. China.
Department of Urology, The First People's Hospital of Foshan, Foshan, Guangdong 528010, P.R. China.
Biomed Rep. 2023 Sep 12;19(5):78. doi: 10.3892/br.2023.1660. eCollection 2023 Nov.
Globally, sleep deprivation is a concerning health issue associated with an increased risk of cardiovascular diseases (CVDs). The present study aimed to explore the association between short-term sleep and the risk of CVDs, taking into consideration sex and age groups. A comprehensive review was conducted by assembling cohort studies that are available in the PubMed, Cochrane Library, and Embase databases. Individuals with ≤5 or ≤6 h of sleep per day were considered as sleep-deprived subjects. To minimize potential bias, two reviewers thoroughly evaluated the selected articles. Relevant data were extracted, and pooled odds ratios (ORs) or relative risks (RRs) were calculated using a random-effects model. In total, 18 cohort studies involving adult subjects were included in the present analysis. The pooled results strongly indicated that sleep deprivation was associated with a greater risk of CVDs [RR: 1.09, 95% confidence interval (CI): 1.02-1.16, P=0.009]. However, when the pooled analysis was stratified by sex and age, the following results were observed: short-term sleep women (RR: 1.06, 95% CI: 0.96-1.17, P=0.27), short-term sleep men (RR: 1.07, 95% CI: 0.97-1.17, P=0.17); ≥18 years-old sleep-deprived population (RR: 1.09, 95% CI: 1.00-1.17, P=0.04), ≥40 years-old sleep-deprived population (RR: 1.09, 95% CI: 0.98-1.22, P=0.11), and subjects with co-existing diseases, such as diabetes and hyperlipidemia (RR: 1.06, 95% CI: 0.94-1.20, P=0.32). In conclusion, short-term sleep is associated with the increased risk of CVDs. Among subjects who were aged ≥18 years-old, there was a strong association with the development of CVDs compared with those who were aged ≥40 years-old. Furthermore, men were at a higher risk of CVDs than women. Adequate sleep (7-8 h per day) may play a role in improving cardiac health. The results of the present study may provide valuable support for further research in public health, highlighting the correlation between sleep deprivation and the risk of CVDs.
在全球范围内，睡眠不足是一个令人担忧的健康问题，与心血管疾病（CVD）风险增加相关。本研究旨在探讨短期睡眠与CVD风险之间的关联，并考虑性别和年龄组因素。通过收集PubMed、Cochrane图书馆和Embase数据库中可用的队列研究进行了全面综述。每天睡眠≤5小时或≤6小时的个体被视为睡眠不足的受试者。为了尽量减少潜在偏差，两名评审员对所选文章进行了全面评估。提取了相关数据，并使用随机效应模型计算了合并比值比（OR）或相对风险（RR）。本分析总共纳入了18项涉及成年受试者的队列研究。汇总结果有力地表明，睡眠不足与CVD风险增加相关[RR：1.09，95%置信区间（CI）：1.02 - 1.16，P = 0.009]。然而，当按性别和年龄进行分层汇总分析时，观察到以下结果：短期睡眠的女性（RR：1.06，95% CI：0.96 - 1.17，P = 0.27），短期睡眠的男性（RR：1.07，95% CI：0.97 - 1.17，P = 0.17）；≥18岁睡眠不足人群（RR：1.09，95% CI：1.00 - 1.17，P = 0.04），≥40岁睡眠不足人群（RR：1.09，95% CI：0.98 - 1.22，P = 0.11），以及患有糖尿病和高脂血症等并存疾病的受试者（RR：1.06，95% CI：0.94 - 1.20，P = 0.32）。总之，短期睡眠与CVD风险增加相关。在≥18岁的受试者中，与≥40岁的受试者相比，CVD发生与短期睡眠的关联更强。此外，男性患CVD的风险高于女性。充足的睡眠（每天7 - 8小时）可能对改善心脏健康起到作用。本研究结果可为公共卫生领域的进一步研究提供有价值的支持，突出睡眠不足与CVD风险之间的相关性。
