Halloran M Elizabeth, Struchiner Claudio J
Biostatistics, Bioinformatics and Epidemiology Program, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, United States.
Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA 98195, United States.
Am J Epidemiol. 2025 Apr 8;194(4):918-920. doi: 10.1093/aje/kwae379.
Over the past 35 years, the term "leaky vaccine" has gained widespread use in both mathematical modeling and epidemiologic methods for evaluating vaccines. Here, we present a short history, as we recall it, of how the term was coined in the context of the history of sporozoite malaria vaccines that were thought in the 1980s to be possibly leaky. We draw a contrast with the all-or-none vaccine mechanism and review a few consequences for study design and population-level effects. We invite readers to contribute information covering the period preceding our memories in the 1980s, because we may have overlooked something.
在过去35年里，“渗漏疫苗”一词在评估疫苗的数学建模和流行病学方法中得到了广泛应用。在此，我们讲述一段我们所记得的该术语在子孢子疟疾疫苗历史背景下如何产生的简史，20世纪80年代人们认为子孢子疟疾疫苗可能存在渗漏情况。我们将其与全或无疫苗机制进行对比，并回顾其对研究设计和人群水平效应的一些影响。我们邀请读者提供涵盖我们20世纪80年代记忆之前时期的信息，因为我们可能有所遗漏。
