Dong Yingkui, Tang Huan, Dai Han, Zhao Hongxin, Wang Junfeng
High Magnetic Field Laboratory, Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, China.
Institute of Physical Science and Information Technology, Anhui University, Hefei, Anhui, China.
Front Chem. 2024 Sep 18;12:1444801. doi: 10.3389/fchem.2024.1444801. eCollection 2024.
The phospholipid bilayer nanodiscs (LNDs), as a rapidly-developing tool in recent years, provide a natural bio-memebrane environment to maintain the native conformation and functions of membrane proteins as well as a versatile delivery vehicle for a variety of hydrophobic and hydrophilic drugs. We have seen unprecedented advantages of phospholipid bilayer nanodiscs in membrane protein structure characterization, biochemical and physiological studies of membrane proteins, membrane environment studies, drug discovery & development, and drug delivery. Many previous reviews have been mainly focused on the advantages of nanodiscs in membrane protein researches, but few have touched upon the importance and potential application of nanodiscs in pharmaceutical industries. This review will provide general description of the structural characteristics, advantages, classification, and applications of phospholipid nanodiscs, with particular focus on nanodisc-enabled membrane protein drug discovery & development as well as drug delivery.
磷脂双层纳米盘（LNDs）作为近年来快速发展的工具，提供了一个天然的生物膜环境来维持膜蛋白的天然构象和功能，同时也是多种疏水和亲水药物的通用递送载体。我们已经看到磷脂双层纳米盘在膜蛋白结构表征、膜蛋白的生化和生理研究、膜环境研究、药物发现与开发以及药物递送方面具有前所未有的优势。许多先前的综述主要关注纳米盘在膜蛋白研究中的优势，但很少涉及纳米盘在制药行业中的重要性和潜在应用。本综述将对磷脂纳米盘的结构特征、优势、分类和应用进行一般性描述，特别关注基于纳米盘的膜蛋白药物发现与开发以及药物递送。
