Saadat Fakhr Masoud, Jadididavodabadi Abolfazl, Rezvanfar Kiana, Amini Zahra, Amiri Koosha, Narimani Zamanabadi Mahnaz
Faculty of Medicine, Tehran Medical Sciences Branch, Islamic Azad University.
Department of Anesthesiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Ann Med Surg (Lond). 2024 Aug 22;86(10):5817-5822. doi: 10.1097/MS9.0000000000002251. eCollection 2024 Oct.
Postoperative pain is a major concern for patients and healthcare providers following abdominal surgery. This study aimed to compare the effectiveness of mexiletine in reducing postoperative pain in patients undergoing abdominal surgery.
In this double-blind randomized controlled trial, 34 patients were divided into two groups. One group received 600 mg of mexiletine tablets, while the other group received vitamin C tablets (control) two hours before surgery. Postoperative pain levels were assessed at 6, 12, and 24 h by using the Visual Analog Scale (VAS). Additionally, the amount of narcotics received within the first 24 h after surgery was recorded.
The results showed that the average postoperative pain score in patients who received mexiletine was significantly lower than in those who received vitamin C tablets (<0.001). Furthermore, the average amount of narcotics received after surgery was significantly lower in the mexiletine group compared to the control group (=0.03). Pain scores at 6, 12, and 24 h after surgery were also significantly lower in the mexiletine group (<0.001).
Mexiletine was effective in reducing postoperative pain and the need for narcotics in patients undergoing abdominal surgery. This study highlights the potential of mexiletine as a valuable preoperative intervention for postoperative pain management.
术后疼痛是腹部手术后患者和医护人员主要关注的问题。本研究旨在比较美西律在减轻腹部手术患者术后疼痛方面的效果。
在这项双盲随机对照试验中，34例患者被分为两组。一组在手术前两小时服用600毫克美西律片，而另一组服用维生素C片（对照组）。术后6小时、12小时和24小时使用视觉模拟评分法（VAS）评估疼痛程度。此外，记录术后24小时内使用的麻醉药量。
结果显示，服用美西律的患者术后平均疼痛评分显著低于服用维生素C片的患者（<0.001）。此外，美西律组术后使用的麻醉药平均量显著低于对照组（=0.03）。美西律组术后6小时、12小时和24小时的疼痛评分也显著更低（<0.001）。
美西律在减轻腹部手术患者术后疼痛及减少麻醉药使用方面有效。本研究凸显了美西律作为术前干预措施在术后疼痛管理中的潜在价值。
