Shrestha Amrita, Baral Abal, Kc Kusha
Koshi Hospital, Biratnagar, Nepal.
Ministry of Health and Population, Nepal.
Ann Med Surg (Lond). 2024 Aug 14;86(10):6190-6193. doi: 10.1097/MS9.0000000000002463. eCollection 2024 Oct.
Pityriasis rubra pilaris is a rare inflammatory papulosquamous disorder which manifests in six clinical subtypes affecting both pediatric and adult populations.
A 14-year-old female presented with multiple itchy scaly lesions on her hands and legs which began as vesicles 9 days after birth. Histopathological examination confirmed the diagnosis of pityriasis rubra pilaris. Further investigations revealed significant peripheral and tissue eosinophilia. The patient was treated with oral isotretinoin, which resulted in the resolution of the lesions.
It is a rare inflammatory papulosquamous disorder characterized by palmoplantar keratoderma and follicular papules coalescing into distinct plaques characterized by a reddish-orange hue and nonadherent flaking scales. The patients with tissue and/or peripheral eosinophilia are usually older at presentation and more likely to have multisite disease. Our patient, in contrast, is a young female which makes this case noteworthy.
This unusual finding of eosinophilia in a young patient underscores the necessity for further research and evaluation to enhance understanding of the pathophysiology of pityriasis rubra pilaris.
红皮病型毛发红糠疹是一种罕见的炎症性丘疹鳞屑性疾病，有六种临床亚型，影响儿童和成人。
一名14岁女性双手和双腿出现多处瘙痒性鳞屑性皮损，出生后9天起病时为水疱。组织病理学检查确诊为红皮病型毛发红糠疹。进一步检查发现外周血和组织中嗜酸性粒细胞显著增多。患者接受口服异维A酸治疗，皮损消退。
这是一种罕见的炎症性丘疹鳞屑性疾病，特征为掌跖角化过度和毛囊丘疹融合成边界清晰的斑块，呈红橙色，有非粘连性鳞屑。组织和/或外周血嗜酸性粒细胞增多的患者通常发病年龄较大，且更易出现多部位病变。相比之下，我们的患者是一名年轻女性，这使得该病例值得关注。
该年轻患者出现嗜酸性粒细胞增多这一不寻常发现，凸显了进一步研究和评估以增进对红皮病型毛发红糠疹病理生理学理解的必要性。
