Islam Salman Ul, Ahmed Muhammad Bilal, Ahsan Haseeb, Islam Mazharul, Shehzad Adeeb, Sonn Jong Kyung, Lee Young Sup
School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Korea.
Department of Pharmacy, Faculty of Life and Environmental Sciences, University of Peshawar, Peshawar 25120, Pakistan.
Antioxidants (Basel). 2020 Sep 25;9(10):916. doi: 10.3390/antiox9100916.
Human skin is continuously subjected to environmental stresses, as well as extrinsic and intrinsic noxious agents. Although skin adopts various molecular mechanisms to maintain homeostasis, excessive and repeated stresses can overwhelm these systems, leading to serious cutaneous damage, including both melanoma and non-melanoma skin cancers. Phytochemicals present in the diet possess the desirable effects of protecting the skin from damaging free radicals as well as other benefits. Dietary phytochemicals appear to be effective in preventing skin cancer and are inexpensive, widely available, and well tolerated. Multiple in vitro and in vivo studies have demonstrated the significant anti-inflammatory, antioxidant, and anti-angiogenic characteristics of dietary phytochemicals against skin malignancy. Moreover, dietary phytochemicals affect multiple important cellular processes including cell cycle, angiogenesis, and metastasis to control skin cancer progression. Herein, we discuss the advantages of key dietary phytochemicals in whole fruits and vegetables, their bioavailability, and underlying molecular mechanisms for preventing skin cancer. Current challenges and future prospects for research are also reviewed. To date, most of the chemoprevention investigations have been conducted preclinically, and additional clinical trials are required to conform and validate the preclinical results in humans.
人类皮肤持续受到环境压力以及外在和内在有害因素的影响。尽管皮肤采用多种分子机制来维持体内平衡，但过度和反复的压力会使这些系统不堪重负，导致严重的皮肤损伤，包括黑色素瘤和非黑色素瘤皮肤癌。饮食中存在的植物化学物质具有保护皮肤免受自由基损伤的理想效果以及其他益处。膳食植物化学物质似乎对预防皮肤癌有效，且价格低廉、广泛可得且耐受性良好。多项体外和体内研究已证明膳食植物化学物质对皮肤恶性肿瘤具有显著的抗炎、抗氧化和抗血管生成特性。此外，膳食植物化学物质影响多个重要的细胞过程，包括细胞周期、血管生成和转移，以控制皮肤癌的进展。在此，我们讨论全果和蔬菜中关键膳食植物化学物质的优势、它们的生物利用度以及预防皮肤癌的潜在分子机制。还回顾了当前的挑战和未来的研究前景。迄今为止，大多数化学预防研究都是在临床前进行的，还需要额外的临床试验来证实和验证在人体中的临床前结果。
